DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2 and atx-2

DIOPT Version :9

Sequence 1:	NP_001359503.1	Gene:	ATXN2 / 6311	HGNCID:	10555	Length:	1155	Species:	Homo sapiens
Sequence 2:	NP_001367241.1	Gene:	atx-2 / 176465	WormBaseID:	WBGene00000231	Length:	1070	Species:	Caenorhabditis elegans

Alignment Length:	1199	Identity:	262/1199 - (21%)
Similarity:	387/1199 - (32%)	Gaps:	431/1199 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    91 GLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTES 155
            |||.         .|..::..:..::|....:...:...|.||....|...|..:....|.:.|:
Worm   117 GLPA---------LNGDVLSAINDMIGRVIIINTTDKKRYSGVLGAVSQDFDFGMQCVVEITKEN 172

Human   156 SSGPKREEIMESILFKCSDFVVVQFKD-MDSSYAKRDAFTDSAIS-----------AKVNGEHKE 208
            .:...|.|      .:|.|.:|..:.| :|.:|..::.....|:|           ..:.||
Worm   173 ENNLLRTE------SECRDKMVFHYSDIVDFAYVTQEIKKQHAVSKFVTDRQYHGDTPIEGE--- 228

Human   209 KDLEPWDAGE------------LTANEELEALENDVSN---GWDPNDMFRYNEENYGVVSTYDSS 258
             :|:.|:.||            :.|..:..|..::..|   ||..||||..||: ..||||:...
Worm   229 -ELQEWNGGEEDGLGGSIEDDVVVAGGQTAARRSNNHNNGTGWSVNDMFAANEK-MNVVSTFKED 291

Human   259 LSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREG 323
            |:.||. :|...::|   ..|||.:||.||||::..|....|||||  :|.....:.|......|
Worm   292 LTQYTT-VEVVGTDE---DRARAERLAREIESNSSSKFMANLENDD--DERDLDKITRQEDFENG 350

Human   324 HSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNG 388
            :......|.:....|:.|                                  |||.
Worm   351 NGRKRNNNSFNQQQQQRR----------------------------------NPNI--------- 372

Human   389 GVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPK 453
                     :|:.:|.:|...|           .|...|.....|   ::.|.:|:||.......
Worm   373 ---------APNGQPVNRRAEG-----------LRGDRRNSGSSS---ANNSRYGAPAAAQQNYS 414

Human   454 RMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVS 518
            :...:...:...:.|....:.:::.|:|. :.|     |:
Worm   415 QNQQQQQGQKGYRRQNEENDWQMAKGKGQ-NQG-----HD------------------------- 448

Human   519 GVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPS 583
                     |..|..::..:...|:..|                       .||...:..|.|.:
Worm   449 ---------HSFRQQQKQMLDPRPNNNV-----------------------KPADDKAQSATTAT 481

Human   584 SEAKDSRLQDQRQNSPAGNKENI--KPNETSPSF-----SKAENKGISPVVSEHRKQIDDLKKFK 641
            :.|..||:.|.:.   .||:.:|  .|.:.:|:.     ..|.|:|
Worm   482 AAAGGSRVTDLKN---WGNEFSIATAPKDQAPAVPAGNSGSAWNRG------------------- 524

Human   642 NDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSG----SSKPNSP 702
                 .|||                    |:       ||.|..|::....|:|    :.|..:|
Worm   525 -----PPSS--------------------LV-------AKGSSNESTPPPTTNGEEAETKKEEAP 557

Human   703 SISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDK---EEKKDAAEQVRKST--LNPNAKEFN 762
            |.|..:.:         ...|.||  :.|.|.::||.   ..:.|:....:.|:  .|.||.||.
Worm   558 STSVDVAA---------APVQNVQ--NDAEKHQEDDNVSVTSENDSVITSKSSSFKFNINAPEFK 611

Human   763 PRSFSQPKPSTTPTSP--RPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIP 825
            ||.......:|||...  .||.||.|:|:..||..|        ||.|        |:.|    |
Worm   612 PRVAPATPTATTPVQNEYHPQQQPHPAMMAPQQGPP--------APGM--------GMVP----P 656

Human   826 MTPMPVNQAKTYRAGKVPNM-----PQQRQ-----DQHHQSAMMH------PASAAGPPIAATPP 874
            ....|.||      |:.|.|     .||:|     .|:||..:.|      |....||. ||||.
Worm   657 HMGGPQNQ------GQPPMMMWQQTGQQQQGGGGYPQNHQFPIQHVPMQGVPGQMYGPG-AATPV 714

Human   875 AYSTQYVAYSPQQFPNQPLVQH-VP--------------HYQSQHPHVYSPVIQGNARMMAPPTH 924
            ..:.|         |||   || ||              .|:.:.| :|.|.   ....|.|.|.
Worm   715 TVAQQ---------PNQ---QHQVPTSAAGGQNHQLRDGEYREKQP-LYMPY---GPPQMVPVTS 763

Human   925 AQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHP 989
            .|     ...:||....|..|.|....:|   :.:|.       |:..|:|..|...:.|
Worm   764 QQ-----FYHSQYQGQMQQAAPYQMKMMP---QQAPQ-------GAYQQRYQQPQVYMMP----- 808

Human   990 QPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQ--QSAIYHAGLAPTPP------- 1045
                 |.||||...   :..|.|.|..|.|..|....:..|.  ||   |....||.|
Worm   809 -----PQGQQQQPR---YQGPPPPQQQQQQQPQQQQFSGEQSRPQS---HPNSQPTTPGPRGELP 862

Human  1046 -------------------SMTPASNTQSPQNSF----------PAAQQTVFTIHPSHVQPAYTN 1081
                               |.:.::::||.|.|.          |..||.....||.|..|.:..
Worm   863 KMSGAPQNGNMQAESSSNASHSGSTSSQSGQRSGSPPGAVPPPPPPQQQHQQQQHPPHHAPPHVG 927

Human  1082 --PPHMAHVPQAHVQSGMVPSHPTAHAPM--------------MLMTTQPP----GGPQAAL-AQ 1125
              ||.|....|.|:|..||...|....|.              |:|..|.|    ..||.:| .:
Worm   928 APPPQMMQQQQQHIQQYMVMQGPHQMHPQIPNYYQQPQALFYPMIMPQQMPMQQNQHPQQSLMGE 992

Human  1126 SALQPIPVSTTAHFPYMTHPSVQAHHQQQ 1154
            .:.|..|  |:.:|.|.|.|:.|...|||
Worm   993 RSDQGFP--TSGYFDYRTMPNYQQQQQQQ 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2	NP_001359503.1	SM-ATX	105..181	CDD:373069	14/75 (19%)
		PBP1	194..>339	CDD:227507	47/170 (28%)
		LsmAD	249..310	CDD:369058	25/60 (42%)
		PRK12323	<408..599	CDD:237057	25/190 (13%)
		PAM2	750..765	CDD:336618	7/16 (44%)
		PHA03247	<769..1087	CDD:223021	99/390 (25%)
atx-2	NP_001367241.1	SM-ATX	126..198	CDD:405176	15/77 (19%)
		LsmAD	283..338	CDD:399606	25/60 (42%)
		Med15	<626..>807	CDD:312941	62/238 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I4034
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm16087
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110