Protein Alignment ATXN2 and atxn2

DIOPT Version :9

• Sequence 1: NP_001359503.1
• Gene: ATXN2 / 6311
• HGNCID: 10555
• Length: 1155
• Species: Homo sapiens
• Sequence 2: XP_002937742.3
• Gene: atxn2 / 100490147
• XenbaseID: XB-GENE-920190
• Length: 1082
• Species: Xenopus tropicalis
• Alignment Length: 1133
• Identity: 870/1133 - (76%)
• Similarity: 959/1133 - (84%)
• Gaps: 69/1133 - (6%)

Human    33 AANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTI 97
            |.|.|||||..:   |||                         ||||..:||||:|.||.||| |
 Frog     7 AGNNRKPGGGSV---PAA-------------------------GGGRQNMGRGRSSGKGPPQS-I 42

Human    98 SFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKRE 162
            ||||||||||:||||||||||||||.||||.|||||||||||||||||||||:|:|||..|||||
 Frog    43 SFDGIYANMRLVHILTSVVGSKCEVFVKNGSIYEGVFKTYSPKCDLVLDAAHKKTTESIVGPKRE 107

Human   163 EIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGE------LTA 221
            :|::|||||.||||:|||||||.:||:||.||||.|::::||||||||||||:.||      .|.
 Frog   108 DIVDSILFKSSDFVMVQFKDMDVNYARRDGFTDSGIASRLNGEHKEKDLEPWNGGENLISSASTV 172

Human   222 NEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAE 286
            :|||::||.|||||||||:|||||||||||||||||||||||||||||||||:|||||||.|:||
 Frog   173 SEELDSLETDVSNGWDPNEMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEYLKREARAAQIAE 237

Human   287 EIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISW--GSG 349
            |||||:|||||||||||:||||||||||||:..||||||:||||||||||.|||::.:.|  .||
 Frog   238 EIESSSQYKARVALENDERSEEEKYTAVQRSLMEREGHSLNTRENKYIPPVQRNKDAMLWTTHSG 302

Human   350 RQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSL 414
            ||.|.|:||.|||.:|||:.||:||::||:|:||||:||||||||||||||||||||||||||||
 Frog   303 RQTSARIGQSGSGPIPSRTGSHSSDYSPNAGADQRVINGGVPWPSPCPSPSSRPPSRYQSGPNSL 367

Human   415 PPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAG 479
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.|
 Frog   368 PPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRTHRVSNG 432

Human   480 RGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSG 544
            ||:|..||||||.|.|.|.:..||||.|.||||||||||||.|||||||||||||   :|:...|
 Frog   433 RGTICGGLEFVSRNEPGEVSAQPVARNSSSGGTWSSVVSGVQRLSPKTHRPRSPR---LGSHAPG 494

Human   545 PVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPN 609
            ..::|||...:|.|:|:||:|||||||||||||||||||.||||||||||||||||..:||.|.:
 Frog   495 SNVSSPQPSTVPPESVSMPVPAASPTPASPASNRAVTPSCEAKDSRLQDQRQNSPAACRENSKQS 559

Human   610 ETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREG-EKSRDLIK 673
            |:  |.||.||| :||:.||.|||:||||||||||||||||:.|::|.|..|||:. ||.||.:|
 Frog   560 ES--SCSKTENK-VSPMASEQRKQLDDLKKFKNDFRLQPSSSPEALDHLTIKNRDSVEKPRDPVK 621

Human   674 DKIEPSAKDSFIENSSSNCTS-GSSKPNSPSISPSILSN-TEHKRGPEVTSQGVQTSSPACKQEK 736
            :|::.:.|:|..|:||:..|| .||||:||||||||:|: :||||||||||||||||.|: ||::
 Frog   622 EKVDANNKESTSESSSNATTSNNSSKPSSPSISPSIISSGSEHKRGPEVTSQGVQTSGPS-KQDR 685

Human   737 DDKEEKKD-AAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQ 800
            |||:::|: |||||||||||||||||||||::||||||||||||||.|||||:||||||||||||
 Frog   686 DDKDDRKENAAEQVRKSTLNPNAKEFNPRSYAQPKPSTTPTSPRPQTQPSPSVVGHQQPTPVYTQ 750

Human   801 PVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSAMMHPASAA 865
            ||||||||||||||||||||||.||||.|||||||||||||||||||||||||||:.||||.|||
 Frog   751 PVCFAPNMMYPVPVSPGVQPLYSIPMTTMPVNQAKTYRAGKVPNMPQQRQDQHHQNTMMHPVSAA 815

Human   866 GPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLV 930
            ||||.|||||||.|||||||||||||||:|||.|||||||||||||||||.||||||:|||.|||
 Frog   816 GPPIVATPPAYSAQYVAYSPQQFPNQPLMQHVQHYQSQHPHVYSPVIQGNTRMMAPPSHAQAGLV 880

Human   931 SSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATP 995
            ||||.||...||||.||                  :||.|||||||||||.||||.|||||||||
 Frog   881 SSSAAQYATPEQTHTMY------------------VSTSSLAQQYAHPNAALHPHPPHPQPSATP 927

Human   996 TGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSF 1060
            |||||||||||||||||||||||||:||||||:.||||||||||||||||:|||.||.||||:||
 Frog   928 TGQQQSQHGGSHPAPSPVQHHQHQASQALHLANQQQQSAIYHAGLAPTPPAMTPGSNAQSPQSSF 992

Human  1061 PAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQ 1125
            | .|||||||||||||.|||||||||||.|||||||||||||||| ||||||.||||||||||||
 Frog   993 P-TQQTVFTIHPSHVQAAYTNPPHMAHVQQAHVQSGMVPSHPTAH-PMMLMTAQPPGGPQAALAQ 1055

Human  1126 SALQPIPVSTTAHFPYMTHPSVQAHHQQ 1153
            ||||||||| ||||.|||||.|||||||
 Frog  1056 SALQPIPVS-TAHFSYMTHPPVQAHHQQ 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2	NP_001359503.1	SM-ATX	105..181	CDD:373069	63/75 (84%)
		PBP1	194..>339	CDD:227507	120/150 (80%)
		LsmAD	249..310	CDD:369058	55/60 (92%)
		PRK12323	<408..599	CDD:237057	154/190 (81%)
		PAM2	750..765	CDD:336618	14/14 (100%)
		PHA03247	<769..1087	CDD:223021	266/317 (84%)
atxn2	XP_002937742.3	SM-ATX	53..126	CDD:405176	60/72 (83%)
		PBP1	139..>290	CDD:227507	120/150 (80%)
		LsmAD	200..261	CDD:399606	55/60 (92%)
		PHA03247	<364..746	CDD:223021	288/388 (74%)
		PRK14971	<450..591	CDD:237874	101/146 (69%)
		PHA03378	<702..944	CDD:223065	216/259 (83%)
		KLF1_2_4_N	<935..1046	CDD:425360	99/112 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	670	1.000	Domainoid score	I1845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2234
Inparanoid	1	1.050	1693	1.000	Inparanoid score	I1046
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54638
OrthoDB	1	1.010	-	-		D121375at7742
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		oto155266
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080