DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN1 and atxn1a

DIOPT Version :9

Sequence 1:	NP_000323.2	Gene:	ATXN1 / 6310	HGNCID:	10548	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_001038291.1	Gene:	atxn1a / 557340	ZFINID:	ZDB-GENE-060503-759	Length:	781	Species:	Danio rerio

Alignment Length:	887	Identity:	406/887 - (45%)
Similarity:	515/887 - (58%)	Gaps:	178/887 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEG--TAWLPGNPGGRGHGGGR-HGP 62
            |||||||||||||||||||||::..||||...:...|....|  .|||...  ..||..|| |
Zfish     1 MKSNQERSNECLPPKKREIPASTLPSEEKPMVMAPANESQRGGNLAWLASL--ASGHDKGRLH-- 61

Human    63 AGTSVELGLQQGIGLHKALSTGLDYSPPS---APRSVPVATTLPAAYATPQPGTPVSPVQYAHLP 124
            ..||.|....|    :|.||...:.:|.|   :.|::...||:||.|.:|...:| |.:||..||
Zfish    62 TSTSAESDGPQ----YKPLSAMAESTPSSSTHSTRALSAVTTIPAVYTSPLSHSP-SAIQYTPLP 121

Human   125 HTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQ 189
            |...|| :..||..||.:| |.|.||.|            |||.:||   |.|:       |.|.
Zfish   122 HNIHFI-NPPYSAPYAGYI-SPLAPPLA------------ATTTTQR---EIYA-------SSSS 162

Human   190 TPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSP 254
            :|..|.:|..|                          |.|..||:|..:.......|||.|:.||
Zfish   163 SPASKIDQHHQ--------------------------LGRPQGLVTTDNTSSPHSTQYVQIAGSP 201

Human   255 QN-TGRTASPP--AIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQ 316
            .: :.||.|.|  .:|:|||||     |||.|..||||::.|.:|   .:|:           ::
Zfish   202 LSISPRTVSSPHTHMPLHLHPH-----HTLPLSGPSQVLVPYTES---LLPK-----------RE 247

Human   317 AIQAKEVLNGEMEKSRRYGAPSSADLGLGK-----AGGKSV----------PHPYESRHVVVHPS 366
            .::.:|:||||:||.||:| ||| :...||     .||.|.          |..:|:||||:
Zfish   248 EMRTRELLNGELEKDRRFG-PSS-ESSAGKQGSTAKGGSSAQQHQIHQQQSPRHFEARHVVL--- 307

Human   367 PSDYSSRDPSGVRASVMVLPNS-NTPAADLEVQQATHREASPSTL-NDKSGLHLGKPGHRSYAL- 428
            |::| ::|.:.:|.|::::||: ::.:||   ......:..|||. ::|.|:..|||..||.:|
Zfish   308 PAEY-TQDSTAMRTSLVLVPNNHSSTSAD---SGGASDKLPPSTSHHEKGGICAGKPVSRSSSLS 368

Human   429 ----------------------SPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYL--SGQQ 469
                                  |||.|||||.:::|.|.:.||:|.||: ||.|:|||.  :|.|
Zfish   369 SSLSFALPPPPVDNLKGAVPAQSPHAVIQTTLNSTESLSLSLPSTNFYS-TQQPIIGYFAGTGHQ 432

Human   470 QAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFN 534
            |.::|..:||||||||||||::|||..|:        |..||:   ||:||.|||:..||.|.|.
Zfish   433 QPLSYHTTLPQHLVIPGTQPVIIPVSGTE--------ATATST---AALPHAFVTSTAPKVETFE 486

Human   535 PEALVTQAAYP----AMVQAQIHLPVVQSVAS-----PAAAPPTLPPYFMKGSIIQLANGELKKV 590
                 :.|.||    ||||||:|||||.:.|.     |..:.|::||||.||||||||:||||:|
Zfish   487 -----SPAPYPHPATAMVQAQLHLPVVPATAGLLTTPPPPSAPSMPPYFTKGSIIQLADGELKRV 546

Human   591 EDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQ 655
            ||||||||||||||||:|||||||||||:.||:...|:||||||..|:|||||||||||||||||
Zfish   547 EDLKTEDFIQSAEISNELKIDSSTVERIDSSHTANFAIIQFAVGAQRSQVSVEVLVEYPFFVFGQ 611

Human   656 GWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKK--GQPVDPASV--LLKHSKA--D 714
            |||||||:||:||.:|||:||||||||||||||||:|||:||  ||.:|..::  .||..||  .
Zfish   612 GWSSCCPDRTTQLLELPCTKLSVGDVCISLTLKNLRNGSIKKSQGQVLDAPALGPPLKSPKALSS 676

Human   715 GLAGSRHRYAEQENGI----NQGS--AQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRR 773
            |..|. .|:.|||||:    :|||  .|...|||||:|.|:... .||.||:.|.|.....||||
Zfish   677 GARGG-VRHTEQENGLGQCADQGSRGGQGNRENGELRFGERDNC-KAPTLTESETSSKPTGRKRR 739

Human   774 WSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815
            |||||.||:|..|.|||||.||||.|||||||.||||||:||
Zfish   740 WSAPEGRKVENPEGEPPLTFPKPSFIPQEVKISIEGRSNIGK 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1	NP_000323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		35/65 (54%)
		polyglutamine repeat	197..225		2/27 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..355		14/40 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		8/27 (30%)
		ATXN-1_C	415..445	CDD:289324	16/52 (31%)
		Self-association. /evidence=ECO:0000269\|PubMed:9097953	494..604		62/118 (53%)
		Interaction with USP7. /evidence=ECO:0000269\|PubMed:12093161	538..815		190/297 (64%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:11136710	540..766		155/246 (63%)
		AXH	573..688	CDD:197779	95/114 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..798		23/35 (66%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	794..797		2/2 (100%)
atxn1a	NP_001038291.1	ATXN-1_C	354..407	CDD:289324	16/52 (31%)
atxn1a	NP_001038291.1	AXH	536..642	CDD:285689	87/105 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326891
Domainoid	1	1.000	194	1.000	Domainoid score	I13318
eggNOG	1	0.900	-	-		E1_KOG4053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H281
Inparanoid	1	1.050	586	1.000	Inparanoid score	I5453
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41409
OrthoDB	1	1.010	-	-		D105079at7742
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		oto50290
orthoMCL	1	0.900	-	-		OOG6_109233
Panther	1	1.100	-	-	LDO	PTHR13392
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3533
SonicParanoid	1	1.000	-	-		X6864
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300