DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATXN1 and Atx-1

DIOPT Version :9

Sequence 1:	NP_000323.2	Gene:	ATXN1 / 6310	HGNCID:	10548	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_572356.1	Gene:	Atx-1 / 31624	FlyBaseID:	FBgn0029907	Length:	230	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	59/154 - (38%)
Similarity:	89/154 - (57%)	Gaps:	26/154 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   567 PPTLPP-----------------YFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSST 614
            ||:|||                 .|.:||.|:||:|.:::|||::||||||||..|...::..:|
  Fly    20 PPSLPPPSQQHWSSNGFSDDSASCFRRGSYIELASGAMRRVEDIRTEDFIQSALRSQLFELREAT 84

Human   615 VERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVG 679
            |.||:.|..|.:..:.|:...|.|::.::|...:|.||:||||:||.|:.:.||::|.|.:|.||
  Fly    85 VVRIDWSGCPSLVTLTFSYDTHHAKMDLQVQPGHPMFVYGQGWASCDPQLSLQLYELKCQQLQVG 149

Human   680 DVCISLTLKNLKNGSVKKGQPVDP 703
            |:|:||         |...||..|
  Fly   150 DICLSL---------VPNEQPAAP 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1	NP_000323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		polyglutamine repeat	197..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424
		ATXN-1_C	415..445	CDD:289324
		Self-association. /evidence=ECO:0000269\|PubMed:9097953	494..604		23/53 (43%)
		Interaction with USP7. /evidence=ECO:0000269\|PubMed:12093161	538..815		59/154 (38%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:11136710	540..766		59/154 (38%)
		AXH	573..688	CDD:197779	50/114 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..798
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	794..797
Atx-1	NP_572356.1	AXH	43..158	CDD:197779	51/123 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144537
Domainoid	1	1.000	111	1.000	Domainoid score	I6242
eggNOG	1	0.900	-	-		E1_KOG4053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4678
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		otm40942
orthoMCL	1	0.900	-	-		OOG6_109233
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.620