DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN1 and Atxn1

DIOPT Version :9

Sequence 1:	NP_000323.2	Gene:	ATXN1 / 6310	HGNCID:	10548	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_036858.1	Gene:	Atxn1 / 25049	RGDID:	3624	Length:	789	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	712/815 - (87%)
Similarity:	731/815 - (89%)	Gaps:	26/815 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGT 65
            ||||||||||||||||||||||||.|||||..||||||.|||.||||..||.|||||||||||||
  Rat     1 MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRGHGGGRHGPAGT 65

Human    66 SVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFI 130
            |.|.|| ||:|||||||.||||||||||||||.|.|||..|..||.||||||||||||.||||||
  Rat    66 SGEHGL-QGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFI 129

Human   131 GSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKA 195
            |||||||.||.|||||||.|..|||||||||||||||||||||||||||||||||||||.||||.
  Rat   130 GSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKV 194

Human   196 EQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRT 260
            |                        ...||||.||.||:.||||||.|||||:|||||||::||.
  Rat   195 E------------------------PPPQQHLGRAAGLVNPGSPPPTQQNQYIHISSSPQSSGRA 235

Human   261 ASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLN 325
            .||| ||||||||||||||||||||.||||:||:|:|.||||||:||||||||||||:|||||||
  Rat   236 TSPP-IPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLN 299

Human   326 GEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNT 390
            |||||||||||.||.:|.|||...||||||||||||||||||:||||||.||||.||||||||:|
  Rat   300 GEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSST 364

Human   391 PAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYA 455
            |:||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   365 PSADLETQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYA 429

Human   456 GTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPH 520
            |.|||||||||.|||||||||.|||||||||||||||||||.||:..|||.||||||||||||||
  Rat   430 GAQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPH 494

Human   521 TFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANG 585
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
  Rat   495 TFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANG 559

Human   586 ELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPF 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   560 ELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPF 624

Human   651 FVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADG 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||:|.|.
  Rat   625 FVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALLKHAKTDS 689

Human   716 LAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR 780
            |||||||||||||||||||||:||||||||||||:||||||||||||||||.|||||||||||:|
  Rat   690 LAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKPTATRKRRWSAPETR 754

Human   781 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815
            |||||||||||||||||||||||||||||||||||
  Rat   755 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1	NP_000323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		54/62 (87%)
		polyglutamine repeat	197..225		0/27 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..355		18/25 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		25/26 (96%)
		ATXN-1_C	415..445	CDD:289324	29/29 (100%)
		Self-association. /evidence=ECO:0000269\|PubMed:9097953	494..604		103/109 (94%)
		Interaction with USP7. /evidence=ECO:0000269\|PubMed:12093161	538..815		267/276 (97%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:11136710	540..766		218/225 (97%)
		AXH	573..688	CDD:197779	114/114 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..798		33/35 (94%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	794..797		2/2 (100%)
Atxn1	NP_036858.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		61/72 (85%)
		PHA03247	<79..241	CDD:223021	132/186 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..237		34/72 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..397		87/100 (87%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P54253	468..578		103/109 (94%)
		Interaction with USP7. /evidence=ECO:0000250\|UniProtKB:P54253	512..789		267/276 (97%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:P54253	514..740		218/225 (97%)
		AXH	547..662	CDD:197779	114/114 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..772		33/35 (94%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	768..771		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83679539
Domainoid	1	1.000	674	1.000	Domainoid score	I3820
eggNOG	1	0.900	-	-		E1_KOG4053
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H281
Inparanoid	1	1.050	1411	1.000	Inparanoid score	I3083
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41409
OrthoDB	1	1.010	-	-		D105079at7742
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		oto141279
orthoMCL	1	0.900	-	-		OOG6_109233
Panther	1	1.100	-	-	LDO	PTHR13392
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6864
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270