DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN1 and Atxn1

DIOPT Version :9

Sequence 1:	NP_000323.2	Gene:	ATXN1 / 6310	HGNCID:	10548	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_001186234.1	Gene:	Atxn1 / 20238	MGIID:	104783	Length:	799	Species:	Mus musculus

Alignment Length:	824	Identity:	709/824 - (86%)
Similarity:	731/824 - (88%)	Gaps:	34/824 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGT 65
            ||||||||||||||||||||||||.|||||..||||||.|||.||||..||.|||||||||.|||
Mouse     1 MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGIRGHGGGRHGSAGT 65

Human    66 SVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFI 130
            |.|.|| ||:|||||||.||||||||||||||.|.|||..|..||.||||||||||||.||||||
Mouse    66 SGEHGL-QGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFI 129

Human   131 GSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKA 195
            |||||||.||.|||||||.|:.|||||||||||||||||||||||||||||||||||||.||||.
Mouse   130 GSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKV 194

Human   196 EQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGS-PPPAQQNQYVHISSSPQNTGR 259
            |                        ...|||||||.||:.||| |||.|||||:|||||||::||
Mouse   195 E------------------------PPPQQHLSRAAGLVNPGSPPPPTQQNQYIHISSSPQSSGR 235

Human   260 TASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVL 324
            ..|||.||||||||||||||||||||.||||:||:|:|.||||||:||||||||||||:||||||
Mouse   236 ATSPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVL 300

Human   325 NGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSN 389
            ||||||||||||.||.:|.||||..||||||||||||||||||:||||||.||||.||||||||:
Mouse   301 NGEMEKSRRYGASSSVELSLGKASSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSS 365

Human   390 TPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFY 454
            ||:||||.||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   366 TPSADLEAQQTTHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFY 430

Human   455 AGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVP 519
            ||||||||||||||||||||||.|||||||||.|||||||||.||:..|||.|||||||||||||
Mouse   431 AGTQPPVIGYLSGQQQAITYAGGLPQHLVIPGNQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVP 495

Human   520 HTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLAN 584
            ||||||||||||||||||||||||||||||||||||||||||||..|.|||||||||||||||||
Mouse   496 HTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPTTASPTLPPYFMKGSIIQLAN 560

Human   585 GELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRA--------QVS 641
            |||||||||||||||||||||||||||||||||||:||||||||||||||||||        |||
Mouse   561 GELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEESHSPGVAVIQFAVGEHRAQVTLTRVIQVS 625

Human   642 VEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASV 706
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   626 VEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASV 690

Human   707 LLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRK 771
            |||.:|.|.|||||||||||||||||||||:||||||||||||:||||||||:|||||||.||||
Mouse   691 LLKQAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLSKIEPSKPTATRK 755

Human   772 RRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815
            |||||||:||||||||||||||||||||||||||||||||||||
Mouse   756 RRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1	NP_000323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		53/62 (85%)
		polyglutamine repeat	197..225		0/27 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..355		19/25 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		24/26 (92%)
		ATXN-1_C	415..445	CDD:289324	29/29 (100%)
		Self-association. /evidence=ECO:0000269\|PubMed:9097953	494..604		101/109 (93%)
		Interaction with USP7. /evidence=ECO:0000269\|PubMed:12093161	538..815		263/284 (93%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:11136710	540..766		214/233 (92%)
		AXH	573..688	CDD:197779	113/122 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..798		33/35 (94%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	794..797		2/2 (100%)
Atxn1	NP_001186234.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		31/34 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..240		37/76 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		90/103 (87%)
		ATXN-1_C	391..421	CDD:289324	29/29 (100%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P54253	470..580		101/109 (93%)
		AXH	549..672	CDD:197779	113/122 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..782		35/37 (95%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:9778246	778..781		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954061
Domainoid	1	1.000	671	1.000	Domainoid score	I4125
eggNOG	1	0.900	-	-		E1_KOG4053
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H281
Inparanoid	1	1.050	1403	1.000	Inparanoid score	I3398
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41409
OrthoDB	1	1.010	-	-		D132768at33208
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		oto125156
orthoMCL	1	0.900	-	-		OOG6_109233
Panther	1	1.100	-	-	LDO	PTHR13392
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3533
SonicParanoid	1	1.000	-	-		X6864
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300