DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATXN1 and K04F10.1

DIOPT Version :9

Sequence 1:	NP_000323.2	Gene:	ATXN1 / 6310	HGNCID:	10548	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_491837.2	Gene:	K04F10.1 / 187002	WormBaseID:	WBGene00019394	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	251	Identity:	76/251 - (30%)
Similarity:	113/251 - (45%)	Gaps:	41/251 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   440 ASEPLPVGL--PATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEAS 502
            ||:...|.|  ||. |..||. ..||.|....||..:...||..:.:....|.|:|..|..:|.:
Worm    19 ASQTGNVNLWNPAN-FLLGTN-STIGQLPPVPQAFHFLPPLPPPITVTPLTPALLPTTSYPVEVA 81

Human   503 --GAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAA 565
              ..||.|.|..|.             |:.....|.........||...
Worm    82 TEDTAPHIKTEEPD-------------PQPSTSEPSIAFEMGTIPASTY---------------- 117

Human   566 APPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQ 630
                .|.:||:|:.:.:|||.:||||||.::||::.|..|:|:.:::|.::.|:.  :.|...|.
Worm   118 ----YPTHFMRGTQLNVANGNIKKVEDLSSDDFLRCAAESDDVIVNASVIKSIKS--TAGSVTII 176

Human   631 FAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLT 686
            |..|..:..:.::..||:||||.|:||.||.|.::.:.:.|.|..|.|.||||.||
Worm   177 FETGIEKQLIPLKCQVEHPFFVLGKGWCSCNPRKSGENYGLDCEILQVDDVCIVLT 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN1	NP_000323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		polyglutamine repeat	197..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424
		ATXN-1_C	415..445	CDD:289324	2/4 (50%)
		Self-association. /evidence=ECO:0000269\|PubMed:9097953	494..604		27/111 (24%)
		Interaction with USP7. /evidence=ECO:0000269\|PubMed:12093161	538..815		48/149 (32%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:11136710	540..766		48/147 (33%)
		AXH	573..688	CDD:197779	45/114 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..798
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P54254	794..797
K04F10.1	NP_491837.2	AXH	121..234	CDD:197779	45/114 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451888
Domainoid	1	1.000	95	1.000	Domainoid score	I5118
eggNOG	1	0.900	-	-		E1_KOG4053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4678
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		otm15008
orthoMCL	1	0.900	-	-		OOG6_109233
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.580