Protein Alignment SATB1 and dve

DIOPT Version :10

• Sequence 1: NP_001182399.1
• Gene: SATB1 / 6304
• HGNCID: 10541
• Length: 795
• Species: Homo sapiens
• Sequence 2: NP_477242.1
• Gene: dve / 37546
• FlyBaseID: FBgn0020307
• Length: 1024
• Species: Drosophila melanogaster
• Alignment Length: 986
• Identity: 192/986 - (19%)
• Similarity: 332/986 - (33%)
• Gaps: 325/986 - (32%)

Human     3 HLNEATQ---GKEHSEMSNNVSDPKGPP--------------AKIARLEQNGSP----------- 39
            |..:|.|   |....|::...|....||              :..|...||.:|
  Fly   131 HQQQAQQAGAGVGSGELAGRRSSEGTPPTAHPPTNSEGQALSSSTASSSQNATPKSDRERERERE 195

Human    40 ------LGRGRL------------GSTGAKMQGVPLKHSG-------HLMKTNLRKGTMLPVFCV 79
                  :.||.:            |...|:.|...|.|..       .:.|.|.:.   ||:.||
  Fly   196 RDREERVERGSISCLPPAALGMAVGVQQAQHQEKLLSHPALDSRREFDVSKVNPKS---LPLHCV 257

Human    80 VEHYEN---AIEYDCKE--------EHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQ 133
            ||...:   ::..|.::        |...:|::.....::::::.||..||||...|..|:|.:.
  Fly   258 VESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLI 322

Human   134 VGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLK 198
            :..|.|:||..::|.|...|:|::.::..|:||:|.:        |.|:......:::.|..||.
  Fly   323 IKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIVI--------LRPKTSPFGEIKDKLLKLLV 379

Human   199 DMNQSSL-AKECPLSQSMISSIVNSTY---YA----NVSAAKCQEFGRWYKH------FKKTKDM 249
            ..:.:.| :..|||.:..:|.|..|::   ||    .:|....::|.:|:.:      ...|..|
  Fly   380 LQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGGEISDELRRKFDQWWSNQLSPQATAMTPKM 444

Human   250 MV----------------EMD------------------------------SLSE-----LSQQG 263
            :.                |||                              |:..     |:.:.
  Fly   445 LPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLANEA 509

Human   264 ANHVNFGQQPVPGNTAEQPPSPAQLS------HGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLV 322
            |:|...||.|.||:.......|...|      ||.......|.|| ....:.|...|::...:
  Fly   510 AHHAGAGQAPGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPN-QKTRMRTSFDPEMELPK-- 571

Human   323 MAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWV-------- 379
                |.:.:|.|...::|.:....:......||...|||        :|::.:| |.
  Fly   572 ----LQKWFADNPHPSRQQIQTYVVQLNALESRRGRKPL--------DVNNVVY-WFKNARAAQK 623

Human   380 RDELKRAGISQAVFA--RVAFNRTQGLLSE--ILRKEEDPKTASQSL-LVNLRAMQNFLQLP--- 436
            |.|::...:..|:.|  ..|.|   |.||:  .|.:.......||.: :.||....::|:.|
  Fly   624 RAEMRGGSLGSAISALGHAAMN---GYLSQHAPLGQNSSSSAGSQPMSMGNLSMSHDYLKSPLSL 685

Human   437 -EAERDRIYQ-----DERERSLNAASAMGPAPLISTPPSR----PPQVKTATIATERNGKPENNT 491
             ..:.|.:.|     ||.:...|...    .||..|...|    |...:....|.|:....|..:
  Fly   686 KSEDIDTMSQHSDDMDEEQSRPNTPQ----LPLSLTTHERHRSSPLMDEDEDEAGEQQQPQEAKS 746

Human   492 MNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFL 556
            ..:|.|:.||.:||..|.::..                   ..||:.:.|:|.|
  Fly   747 DGMNGSVKDEERQEKSRDELQD-------------------NEKENSNGEDRHL----------- 781

Human   557 SLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQSPSPTTLGK-------------GESRGV 608
                 :.||..|..||..::|.:..   :|:..|...:|..:|..:             .|:...
  Fly   782 -----DADAQMEASSNLNNNHNNSS---LHIEQEVGSTPKRSTPKEEDDDLDMDEDEEDNENDAS 838

Human   609 FLPGLPTPAPWL--GAAPQQQQQQQQQQQQQQQAPPPPQPQQQ------------PQTGPRL--- 656
            .|....:|:|.|  |..|           .:.|.|.|..|...            |..|...
  Fly   839 HLDEFRSPSPDLAGGVVP-----------HKDQLPFPMVPNSMFSQSFMYMSHYIPAFGQAAAGH 892

Human   657 PPRQPTVASPAE------------------SDEENRQKTR----PRTKI----------SVEALG 689
            |......|:.|.                  |:||.|::.|    |.|::          :..:..
  Fly   893 PHHHAAAAAAAAGIQPNALMGGGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHN 957

Human   690 ILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLK----DNS------GL 744
            ::..:.:|:...|..:....|.::      .:..:|:|:|...|   :||    |::      ||
  Fly   958 LILKYTEDLNTMPYRQKFPRLESK------NVQFWFKNRRAKCK---RLKMSLYDSNQCAQLGGL 1013

Human   745 EVDVAEYKEEE 755
            ...|.:|:|.:
  Fly  1014 GSFVPKYEERD 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SATB1	NP_001182399.1	ULD	72..170	CDD:465165	30/108 (28%)
		CUTL	176..247	CDD:435427	17/84 (20%)
		CUT	372..444	CDD:460543	19/88 (22%)
		CUT	497..567	CDD:460543	13/69 (19%)
		HOX	676..733	CDD:197696	9/70 (13%)
dve	NP_477242.1	ULD	250..359	CDD:465165	30/111 (27%)
		HOX	556..623	CDD:197696	14/81 (17%)
		HOX	928..995	CDD:197696	10/72 (14%)