DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CELA2A and CG32260

DIOPT Version :9

Sequence 1:	NP_254275.1	Gene:	CELA2A / 63036	HGNCID:	24609	Length:	269	Species:	Homo sapiens
Sequence 2:	NP_728942.1	Gene:	CG32260 / 317943	FlyBaseID:	FBgn0052260	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	275	Identity:	97/275 - (35%)
Similarity:	146/275 - (53%)	Gaps:	37/275 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    11 VAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQY---SSNGKWYHTCGGSLIANSWVLTAA 72
            ::||.|          .|||||.|||..::||..:|.|   ::.......||||||.:.:|:|:|
  Fly   320 ISGATS----------NRVVGGMEARKGAYPWIAALGYFEENNRNALKFLCGGSLIHSRYVITSA 374

Human    73 HCISSSRTYRVGLGRHNL-YVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDK 136
            |||:...|. |.||.|:| ..||||::.:.:.:.|||:.::.|.||  |||||::|....:|...
  Fly   375 HCINPMLTL-VRLGAHDLSQPAESGAMDLRIRRTVVHEHFDLNSIS--NDIALIELNVVGALPGN 436

Human   137 IQLACLPPAGTILPNNY----PCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSV- 196
            |...|||.|...:..::    | :|.|||.::..|....||:..::.:|...:|..|.   .|:
  Fly   437 ISPICLPEAAKFMQQDFVGMNP-FVAGWGAVKHQGVTSQVLRDAQVPIVSRHSCEQSY---KSIF 497

Human   197 -----KTSMICAGGDGVISSCNGDSGGPLNCQASDG---RWQVHGIVSFGSRLGCNYYHKPSVFT 253
                 ...::|||...| .:|.|||||||.....:|   |:.:.|:||||..  |...:.|.|:|
  Fly   498 QFVQFSDKVLCAGSSSV-DACQGDSGGPLMMPQLEGNVYRFYLLGLVSFGYE--CARPNFPGVYT 559

Human   254 RVSNYIDWINSVIAN 268
            ||::|:.||...||:
  Fly   560 RVASYVPWIKKHIAS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELA2A	NP_254275.1	Tryp_SPc	29..265	CDD:238113	91/252 (36%)
CG32260	NP_728942.1	CLIP	194..244	CDD:288855
		Tryp_SPc	327..568	CDD:214473	90/250 (36%)
		Tryp_SPc	328..571	CDD:238113	91/252 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8300
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940