Protein Alignment MAPK12 and HOG1

DIOPT Version :10

• Sequence 1: NP_002960.2
• Gene: MAPK12 / 6300
• HGNCID: 6874
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_013214.1
• Gene: HOG1 / 850803
• SGDID: S000004103
• Length: 435
• Species: Saccharomyces cerevisiae
• Alignment Length: 342
• Identity: 165/342 - (48%)
• Similarity: 222/342 - (64%)
• Gaps: 6/342 - (1%)

Human    11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75
            |.|.::..|.:|:...|.||.|||.||:|.||||.|..|...|||||:.:||.:.:.|||.||||
Yeast     7 FIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYREL 71

Human    76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
            :||||:||||:|.|.|:|     |....|.|.|....||||.:|::...|.:..:|:.:||:|:|
Yeast    72 KLLKHLRHENLICLQDIF-----LSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRG 131

Human   141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205
            |:|:|:||:|||||||.|:.:||:|:|||.||||||..|.:|||||.||:|||||::|.|.:|..
Yeast   132 LKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDV 196

Human   206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270
            .|||||.|||.||||.||.||.|.||:.|...|..:.|:||.:.:..:.|:....::..||..:.
Yeast   197 EVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDP 261

Human   271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQ-KYDDSFDDVD 334
            ..|:.......|.||:|||||||.|.::|:||.:||||||....||..|||... |:|..|:|.|
Yeast   262 IPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAKFDWHFNDAD 326

Human   335 RTLDEWKRVTYKEVLSF 351
            ..:|.|:.:.|.|:|.|
Yeast   327 LPVDTWRVMMYSEILDF 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	165/342 (48%)
		TXY	183..185		1/1 (100%)
HOG1	NP_013214.1	STKc_Sty1_Hog1	12..339	CDD:270843	160/331 (48%)