DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPK12 and mapk12b

DIOPT Version :9

Sequence 1:	NP_002960.2	Gene:	MAPK12 / 6300	HGNCID:	6874	Length:	367	Species:	Homo sapiens
Sequence 2:	NP_001038306.1	Gene:	mapk12b / 557810	ZFINID:	ZDB-GENE-041210-123	Length:	364	Species:	Danio rerio

Alignment Length:	361	Identity:	250/361 - (69%)
Similarity:	299/361 - (82%)	Gaps:	1/361 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71
            :|:||||||:.:|.|:|...||||..:|:||||.||||:|.:||.:||||||:|||||.||||||
Zfish     5 SRAGFYRQEINRTVWDVPERYRDLIQIGTGAYGTVCSAIDRKTGVRVAIKKLHRPFQSRLFAKRA 69

Human    72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQ 136
            ||||||||||:||||||||||||.:..||.|.||||||||||||||||||.|:|.|||:||||||
Zfish    70 YRELRLLKHMKHENVIGLLDVFTSEILLDRFHDFYLVMPFMGTDLGKLMKMERLCEDRVQFLVYQ 134

Human   137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201
            :|:||:|||:||||||||||||||||::|||||||||||||||||||||||||||||||||||||
Zfish   135 ILRGLKYIHSAGIIHRDLKPGNLAVNQNCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 199

Human   202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266
            .|:|||||||||||||||:.|:|||||:||||||:||||:||||..:|:.:|||.:||||::|||
Zfish   200 HYSQTVDIWSVGCIMAEMLLGRTLFKGNDHLDQLREIMKITGTPAPDFITKLQSQDAKNYIRGLP 264

Human   267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFD 331
            ::.|||..:|...||..||:.||.|||||.::||:|.|||..|.|....:.|:|.:...||.|.|
Zfish   265 KVPKKDLNTIFFKASSEAVSALELMLVLDPDKRVSAAEALELPLFTEFREPEEETEALPYDHSMD 329

Human   332 DVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 367
            :.:..||:|||.|:.|:|||:|| ....|.||||.|
Zfish   330 NTELPLDQWKRHTFTEILSFQPP-VTEIRDSKETSL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	240/341 (70%)
MAPK12	NP_002960.2	TXY	183..185		1/1 (100%)
mapk12b	NP_001038306.1	PKc_like	9..351	CDD:304357	240/341 (70%)
mapk12b	NP_001038306.1	S_TKc	25..307	CDD:214567	214/281 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340307
Domainoid	1	1.000	450	1.000	Domainoid score	I3563
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55705
Inparanoid	1	1.050	516	1.000	Inparanoid score	I6293
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D235398at7742
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		otm27795
orthoMCL	1	0.900	-	-		OOG6_112498
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6171
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.290