Protein Alignment MAPK12 and rl

DIOPT Version :9

• Sequence 1: NP_002960.2
• Gene: MAPK12 / 6300
• HGNCID: 6874
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 357
• Identity: 151/357 - (42%)
• Similarity: 225/357 - (63%)
• Gaps: 17/357 - (4%)

Human     5 PPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69
            |.:.:...|.::    :||...|..|..:|.||||.|.||.|..|..:|||||: .||:.:.:.:
  Fly    20 PQSNAEVIRGQI----FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQ 79

Human    70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLV 134
            |..||:.:|...:|||:|.:.|:...| ::|...|.|:|...|.|||.||:|.::|..|.|.:.:
  Fly    80 RTLREITILTRFKHENIIDIRDILRVD-SIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFL 143

Human   135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRA 193
            ||:|:||:|||:|.::||||||.||.:|:.|:|||.||||||.||.|      :|.||.||||||
  Fly   144 YQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 208

Human   194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258
            ||::||...||:::||||||||:|||::.:.:|.|..:||||..|:.|.|:|..:.::.:.:::|
  Fly   209 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKA 273

Human   259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQV 323
            :||::.||......:|.:..||..||::||.|||..:..:|:...|||||||.|..:|..|||..
  Fly   274 RNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVA 338

Human   324 Q---KYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
            :   :.:...||:.|  |..|.:.::|.|.||
  Fly   339 EVPFRINMENDDISR--DALKSLIFEETLKFK 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	150/351 (43%)
		TXY	183..185		1/1 (100%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	146/337 (43%)
		S_TKc	38..326	CDD:214567	132/289 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810