Protein Alignment MAPK12 and sty1

DIOPT Version :10

• Sequence 1: NP_002960.2
• Gene: MAPK12 / 6300
• HGNCID: 6874
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_592843.1
• Gene: sty1 / 2541652
• PomBaseID: SPAC24B11.06C
• Length: 349
• Species: Schizosaccharomyces pombe
• Alignment Length: 342
• Identity: 171/342 - (50%)
• Similarity: 230/342 - (67%)
• Gaps: 6/342 - (1%)

Human    11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75
            |.|.::..|.:|:...|.||||:|.||:|.||||.|..||..||:||:.:||.:.:.|||.||||
pombe     4 FIRTQIFGTCFEITTRYSDLQPIGMGAFGLVCSAKDQLTGMNVAVKKIMKPFSTPVLAKRTYREL 68

Human    76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
            :||||:||||:|.|.|:|     :..|.|.|.|...:||||.:|:....|....||:.:||:|:|
pombe    69 KLLKHLRHENIISLSDIF-----ISPFEDIYFVTELLGTDLHRLLTSRPLETQFIQYFLYQILRG 128

Human   141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205
            |:::|:||:|||||||.|:.:||:|:|||.||||||..|.:|||||.||:|||||::|.|.:|..
pombe   129 LKFVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYNV 193

Human   206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270
            .|||||.|||.||||.||.||.|.||::|...|.::.||||.|.::.:.|.....:::.||:.||
pombe   194 EVDIWSAGCIFAEMIEGKPLFPGRDHVNQFSIITELLGTPPMEVIETICSKNTLRFVQSLPQKEK 258

Human   271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQK-YDDSFDDVD 334
            ..||....||.|.|::|||||||.|..:|::|.:||||.|....||..|||...: :|.||.|.|
pombe   259 VPFAEKFKNADPDAIDLLEKMLVFDPRKRISAADALAHNYLAPYHDPTDEPVADEVFDWSFQDND 323

Human   335 RTLDEWKRVTYKEVLSF 351
            ..::.||.:.|.|||||
pombe   324 LPVETWKVMMYSEVLSF 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	171/342 (50%)
		TXY	183..185		1/1 (100%)
sty1	NP_592843.1	STKc_Sty1_Hog1	9..336	CDD:270843	164/331 (50%)