DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SALL1 and salm

DIOPT Version :9

Sequence 1:	NP_002959.2	Gene:	SALL1 / 6299	HGNCID:	10524	Length:	1324	Species:	Homo sapiens
Sequence 2:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster

Alignment Length:	1361	Identity:	370/1361 - (27%)
Similarity:	543/1361 - (39%)	Gaps:	461/1361 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    79 ASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGS 143
            |||..  ||.|..:.|:||.....:..:| ...|....|.:..|...|:|....|.:....:..|
  Fly    72 ASPSR--SPEPEEEQPEEQSTSEQSIPEQ-STPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPS 133

Human   144 HSSTAPSSSSSSSSSSGGGGSSSTGTS---------------------AITTSLPQLGDLTTLGN 187
            .....|::|.|..||.....|:....:                     |.::::|.. ::|..|.
  Fly   134 SEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPST-EVTLPGG 197

Human   188 FSVINSNVIIENLQSTKVAVAQFSQEARCGGASGG-------KLAVPALMEQLLALQQQQIHQLQ 245
               ..:.|.:|.:|:.::|:|||:.:....|::|.       :||.  |.:.|..|||||:.|:|
  Fly   198 ---AGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAF--LQQTLFNLQQQQLFQIQ 257

Human   246 LIEQIRHQILL-LASQNADLPTSSSPSQG-TLRTSANPLSTLSSHLSQQLAAAAGLAQSLASQSA 308
            ||:|::.|:.| .|.|..|....:...|. ...|.........:.:..:..|.|.:|::.|.|..
  Fly   258 LIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHL 322

Human   309 SISGVKQLPPIQLPQSSSGNTIIPSNS---------GSSPNMNILAAAVTTPSSEKVASSAGASH 364
            ..:||    |:   :.|||:   |:.|         .|.||..        ||.:.       :|
  Fly   323 INAGV----PL---RESSGS---PAESLKRRREHDHESQPNRR--------PSLDN-------TH 362

Human   365 VSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVFPSPLPNIGTTAEDL---NSLSALAQQR 426
            .::.|..       |::.|....:.||......|:|:.        |..:||   |||..|.::.
  Fly   363 KADTAQD-------ALAKLKEMENTPLPFGSDLASSII--------TNHDDLPEPNSLDLLQKRA 412

Human   427 KSKPPNVT------------AFEAKSTS----DEAFFKHKCRFCAKVFGSDSALQIHLRSHTGER 475
            :....:.:            ||..||..    :|.||||:||:|.||||||||||||:|||||||
  Fly   413 QEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGER 477

Human   476 PFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNI---------PTSTG------ 525
            |||||:||:||:||||||||||||.:|:||:.||..|:|||:|..         ||.:.
  Fly   478 PFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPA 542

Human   526 -IPYG---MSIPPEKPVTSWLDTKPVLPTLTTSVGLPLP----------------PTLPSLIPFI 570
             .|.|   .|.||..|....|...|:  .:..|:|...|                |.|....|.:
  Fly   543 PPPLGSAPASFPPAFPGLQNLYRPPM--EILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQV 605

Human   571 KTE---------------------EPAPIPI---------------------------------- 580
            |.|                     ||.|:|:
  Fly   606 KNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEH 670

Human   581 --------SHSATSP------PGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEE----S 627
                    ||....|      |.::......|.|.: :|..||...:   |||......|    :
  Fly   671 RSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQS-HLDHLPTPGQ---LPPREDFFAERFPLN 731

Human   628 GMVTNSVPTASSSVLSSPAADCGPAG------------SATTFTNPLLPLMSEQFKAKFP----- 675
            ......:.....|.:.|||....|.|            :.:.|.||:    ..:..|..|
  Fly   732 FTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPI----KHEMAALLPRPHSN 792

Human   676 ---FGGLLDSAQASETSKLQQLVENIDKKATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCK 737
               :...::.:...||.||::|::|  ||.:|||:|::|.|||||:|||:||||||||||||||:
  Fly   793 DNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCR 855

Human   738 ICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMG------------ 790
            |||||||||||||||.:||:..||:|..|.||:|.||::||:|||||||:|.|
  Fly   856 ICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQA 920

Human   791 --------------------------GQIP----NTPVPDSYSES----MESDTGSFDE-----K 816
                                      |.:|    ..|.|:..:.:    .||..|..|:     :
  Fly   921 AEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGE 985

Human   817 NFDD---LDNFSDENME------------------------------------------------ 830
            ::||   .::.|:.|:|
  Fly   986 DYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVG 1050

Human   831 --------------------------DCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQ 869
                                      :..:|::..||::|..|..| |.||||.|
  Fly  1051 STSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSS-SRSPLPKE---------- 1104

Human   870 MKMINAGLAEQLQASLKSVENGS--IEGDVLTND-SSSVGGD-----------------MESQSA 914
             |.::       ..||....:||  ...::||:. ..:||.|                 |:.|:|
  Fly  1105 -KPVS-------PPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAA 1161

Human   915 GSPAISESTSSMQALSPSNSTQEFHKSPSIEEK---------------PQRAVPSEFAN------ 958
            .:.|.:......|.::..:..||..:..:.|.:               .||..|.:..:
  Fly  1162 VAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGG 1226

Human   959 ---GLSPTPVNGGA--------LDL----TSSHAEKIIKEDSLGIL--FPFRD------RGKFKN 1000
               |..|.|:.|..        |.|    |:.:....:.:.:..::  .||..      ||   :
  Fly  1227 PGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRG---S 1288

Human  1001 TACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLF 1061
            |.|.||.|||.|.|||:||||||||||||.|::|:|||:||||||||||||::||:..:.|
  Fly  1289 TTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETF 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SALL1	NP_002959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..172		8/60 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..336		6/27 (22%)
		C2H2 Zn finger	451..471	CDD:275368	16/19 (84%)
		zf-H2C2_2	463..488	CDD:290200	21/24 (88%)
		C2H2 Zn finger	479..499	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..646		17/120 (14%)
		C2H2 Zn finger	708..728	CDD:275368	14/19 (74%)
		zf-H2C2_2	720..745	CDD:290200	22/24 (92%)
		C2H2 Zn finger	736..756	CDD:275368	16/19 (84%)
		zf-C2H2	766..788	CDD:278523	15/21 (71%)
		C2H2 Zn finger	768..788	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..856		22/193 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..963		17/110 (15%)
		C2H2 Zn finger	1003..1023	CDD:275370	14/19 (74%)
		zf-H2C2_2	1015..1040	CDD:290200	19/24 (79%)
		zf-C2H2	1029..1051	CDD:278523	16/21 (76%)
		C2H2 Zn finger	1031..1051	CDD:275370	15/19 (79%)
		lambda-1	1064..>1155	CDD:212564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1120
		zf-C2H2	1134..1156	CDD:278523
		C2H2 Zn finger	1136..1156	CDD:275368
		zf-H2C2_2	1148..1173	CDD:290200
		C2H2 Zn finger	1164..1184	CDD:275368
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	14/19 (74%)
		zf-H2C2_2	838..863	CDD:290200	22/24 (92%)
		zf-C2H2_2	854..922	CDD:289522	38/67 (57%)
		C2H2 Zn finger	854..874	CDD:275368	16/19 (84%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	14/19 (74%)
		zf-H2C2_2	1303..1328	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1319..1339	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11476
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1625
Isobase	1	0.950	-	0	Normalized mean entropy	S5659
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm41403
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	12.000