DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SALL2 and salm

DIOPT Version :9

Sequence 1:	XP_011535366.1	Gene:	SALL2 / 6297	HGNCID:	10526	Length:	1043	Species:	Homo sapiens
Sequence 2:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster

Alignment Length:	1412	Identity:	329/1412 - (23%)
Similarity:	478/1412 - (33%)	Gaps:	523/1412 - (37%)

- Green bases have known domain annotations that are detailed below.

Human     5 KQRKPQQLISDCE-GPSASENGDASEEDHPQVCAKCCA---QFTDPTEFLAHQNACSTDPPVMVI 65
            ||.|.:...:|.: |....|||..|    |...|...|   :..:|.|....:.:.|...
  Fly    39 KQLKDRARSADKDIGSDQEENGGCS----PLTTATTTASPSRSPEPEEEQPEEQSTSEQS----- 94

Human    66 IGGQENPNN-------SSASSEPRPEGHNNPQVMDTEHSN---PPDSGSSVPTDPTWGPERRGEE 120
            |..|..|::       |.|.||..|...||.:|..|:.|:   .|::..|:|:.|.  .|...||
  Fly    95 IPEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPV--AEASAEE 157

Human   121 SSGHFLVAATGTAAGGGGGLILASPKLGATP------------LPPESTPAPPPPPPPPPPPGVG 173
                   |||                 ..||            ..|:..|:...|......|| |
  Fly   158 -------AAT-----------------ERTPEKEKEKDVEVDVEKPDEAPSSAVPSTEVTLPG-G 197

Human   174 SGHLNIPLILEELR--------------------------------------VLQQRQIHQMQMT 200
            :|   .|:.||.::                                      .|||:|:.|:|:.
  Fly   198 AG---APVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLI 259

Human   201 EQICRQVLL-------------------------------LGSLGQTVGAPASPSELPGTGTASS 234
            :|:..|:.|                               :..:.....|.|..:|      |.:
  Fly   260 QQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAE------AKA 318

Human   235 TKPLLPLFSPIKPVQTSKTLASSSSSSSSSSGAETPKQAFFHLYHPLGSQHPFSAGGVGRSHKPT 299
            .:.|:....|::              .||.|.||:.|:...|.:....::.|    .:..:||..
  Fly   319 RQHLINAGVPLR--------------ESSGSPAESLKRRREHDHESQPNRRP----SLDNTHKAD 365

Human   300 PA----------PSPALPGSTD--QLIASPH--LAFPSTTGLLAAQCLGAARGLEATASPGLLKP 350
            .|          .:..||..:|  ..|.:.|  |..|::..||..:    |:.:..:||.|:| .
  Fly   366 TAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKR----AQEVLDSASQGIL-A 425

Human   351 KNGSGELSYGEVMGP---LEKPGGRHKCRFCAKVFGSDSALQIHLRSHTGERPYKCNVCGNRFTT 412
            .:.:.:.::||..|.   ..:|..:|:||:|.||||||||||||:||||||||:||||||:||||
  Fly   426 NSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTT 490

Human   413 RGNLKVHFHRHREKYPHVQMNPHPVPEH--------LDYVITSSGLPYGMSVPPEKAEEEAATPG 469
            :|||||||.||.:|:|||.||..|:|||        ||.:..:...|.....||......|:.|.
  Fly   491 KGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPP 555

Human   470 G--GVER--KPLVASTTALSATESLTLLSTSAGT---ATAPGLPAFNKFVLMKAVEPKNKADENT 527
            .  |::.  :|.:....:|.|............|   ..:|.|......|..:.||.|::.:|:.
  Fly   556 AFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHE 620

Human   528 PPGSEGSAIS--------GVAESSTATRMQLSK-------LVTSLPSWALLTNHFKSTGSFPFPY 577
            ...:|.|...        .:.|.....:.|:.:       ..|..||....:.|........:|.
  Fly   621 QEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPP 685

Human   578 VLEPL--------GASPSETSKLQQL-------------VEKIDRQGAVA----------VTSAA 611
            |::|:        .:||...|.|..|             .|:.......|          |.|.|
  Fly   686 VVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPA 750

Human   612 SGAPTTSAPAP------------------------------------------------------ 622
            .||.....|.|
  Fly   751 GGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELM 815

Human   623 SSSASSGPNQCVICLRVLSCPRALRLHYGQHGGERPFKCKVCGRAFSTRGNLRAHFVGHKASPAA 687
            .:...|.|||||:|.|||||..||::||..|.|||||||::|||||:|:|||:.|...||..|..
  Fly   816 KNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPM 880

Human   688 RAQNSCPICQKKFTNAVTLQQHVRMHLG------------------------------------- 715
            |..:.||:|.||::||:.||||:|:|.|
  Fly   881 RNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFH 945

Human   716 -GQIPNGGTALPEGGGAAQENGSEQSTVSGARSFPQQQSQQPSPEEELSEEEEEEDE-------- 771
             |.:| ||...|.|......||:..|           :|.|...::.:...|:.:|:
  Fly   946 FGALP-GGPGGPPGPNHGAHNGALGS-----------ESSQGDMDDNMDCGEDYDDDVSSEHLSN 998

Human   772 ---EEEED-----------------------------VTDEDSLAGRGSESGGEKA---ISVRGD 801
               |:|.|                             |....|.:..|...|...|   .||...
  Fly   999 SNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHAS 1063

Human   802 SE----EASGAEEEVG------TVAAAATAGKEMDS---NEKTTQQSSLP--------------- 838
            |:    .:|.|..|..      |..||.|:.....|   .||.....|||
  Fly  1064 SQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILT 1128

Human   839 -PPPPPDSLD------------QPQPMEQGSSGVLGG---------------------------- 862
             |.||...:|            |.|.:.|..:.|...
  Fly  1129 SPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEA 1193

Human   863 ----------------------------KEEGG-------KPERSSSPASALTPE----GEATSV 888
                                        ::|||       .|...:.|...:.|.    ..||:.
  Fly  1194 QQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQ 1258

Human   889 TLVEELS--LQEAMRKEP-------GESSSRKACEVCGQAFPSQAALEEHQKTHPKEGPLFTCVF 944
            .:...::  .|..|...|       |...| ..|.:|.:.||..:|||.|.::|.||.| |.|..
  Fly  1259 NMCNAMNQIAQSVMPAAPFNPLALSGVRGS-TTCGICYKTFPCHSALEIHYRSHTKERP-FKCSI 1321

Human   945 CRQGFLERATLKKHMLLAH---------HQNQYVAFLSNGLPMKPWN 982
            |.:||..:..||:|| |.|         .:|:.|.::|.      ||
  Fly  1322 CDRGFTTKGNLKQHM-LTHKIRDMEQETFRNRAVKYMSE------WN 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SALL2	XP_011535366.1	C2H2 Zn finger	375..395	CDD:275368	16/19 (84%)
		zf-H2C2_2	387..412	CDD:290200	21/24 (88%)
		C2H2 Zn finger	403..423	CDD:275368	16/19 (84%)
		C2H2 Zn finger	633..653	CDD:275368	12/19 (63%)
		zf-H2C2_2	645..670	CDD:290200	17/24 (71%)
		C2H2 Zn finger	661..681	CDD:275368	11/19 (58%)
		zf-C2H2	692..713	CDD:278523	12/20 (60%)
		C2H2 Zn finger	693..713	CDD:275368	12/19 (63%)
		C2H2 Zn finger	913..933	CDD:275370	8/19 (42%)
		C2H2 Zn finger	942..959	CDD:275370	6/16 (38%)
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	12/19 (63%)
		zf-H2C2_2	838..863	CDD:290200	17/24 (71%)
		zf-C2H2_2	854..922	CDD:289522	29/67 (43%)
		C2H2 Zn finger	854..874	CDD:275368	11/19 (58%)
		C2H2 Zn finger	886..906	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	13/25 (52%)
		C2H2 Zn finger	1319..1339	CDD:275368	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41403
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850