Protein Alignment SAG and Arr1

DIOPT Version :10

• Sequence 1: NP_000532.2
• Gene: SAG / 6295
• HGNCID: 10521
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_476681.1
• Gene: Arr1 / 35078
• FlyBaseID: FBgn0000120
• Length: 364
• Species: Drosophila melanogaster
• Alignment Length: 360
• Identity: 158/360 - (43%)
• Similarity: 225/360 - (62%)
• Gaps: 11/360 - (3%)

Human    13 NHVIFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVK-GKKVYVTLTCAFRYGQEDI 76
            |..:|||.|.:..:|:|:..||::|.|:||:|:||::::|.:.|: .:|::|.|.|.||||:||.
  Fly     4 NFKVFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDD 68

Human    77 DVIGLTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTYPFLLTFPDYLPCSVMLQPAPQ 141
            ::|||.|:::|.....||.||.......||:||.||||||||.|||::..|...|.||:||....
  Fly    69 EMIGLRFQKELTLVSQQVCPPQKQDIQLTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKAS 133

Human   142 DSGKSCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRKVQHAPLEMGPQPRAEAAWQFFMSDKP 206
            |..:.|||.:.||.|..||   :.|:..::|::.|.|||||:||.:.|.||.......|.:|...
  Fly   134 DESQPCGVQYFVKIFTGDS---DCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSPGE 195

Human   207 LHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVVLYSSDYYVKPVAMEEAQEK 271
            |.|.|:|:|::|.|||.|.|.:.|.||:.|.||||||.|:|..:|||:.:..:...:|..|..|.
  Fly   196 LELEVTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEG 260

Human   272 VP--PNSTLTKTLTLLPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIK 334
            .|  |.|:|.|.:.|:|.|..|.:|.|||::|.||.:||.|||:|:|.....|...||:|||.:|
  Fly   261 CPLNPGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVK 325

Human   335 VKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAK 369
            |||    |||.| ..|:..|:||.||||:|...|:
  Fly   326 VKL----FLGAL-GGELCAELPFILMHPKPSRKAQ 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAG	NP_000532.2	Arrestin_N	26..184	CDD:451447	70/158 (44%)
		Arrestin_C	203..364	CDD:214976	75/162 (46%)
Arr1	NP_476681.1	Arrestin_N	17..173	CDD:451447	70/158 (44%)
		Arrestin_C	192..350	CDD:214976	75/162 (46%)