Protein Alignment RYR2 and SSH4

DIOPT Version :10

• Sequence 1: XP_006711865.1
• Gene: RYR2 / 6262
• HGNCID: 10484
• Length: 4985
• Species: Homo sapiens
• Sequence 2: NP_012798.1
• Gene: SSH4 / 853735
• SGDID: S000001607
• Length: 579
• Species: Saccharomyces cerevisiae
• Alignment Length: 592
• Identity: 110/592 - (18%)
• Similarity: 202/592 - (34%)
• Gaps: 190/592 - (32%)

Human  3769 TGPMVAATLKLGIAILNGGNSTVQQKML-----------------DYLKEK----KDVGFFQSLA 3812
            |.||.:.:..:.:|.|...:.|....||                 :|.:|.    :..|...||.
Yeast    33 TPPMDSDSAAISLAFLISLSITFAILMLILVVIAAYVTFCGDDESEYDEENALGTRTSGTLHSLF 97

Human  3813 GLMQSCSVLDLN-----AFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF---RFLQLLCEGHN 3869
            |...|..:||.:     .|:.:       :|.:|...|::.:...:..:|:   :..|::.....
Yeast    98 GKKHSGILLDSSFASPGGFDDE-------IVLQERELEELPKMSAYEVELYIRAKEFQMMSPPMV 155

Human  3870 SDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQV 3934
            .||..||.:.              |........|..::...|..|.|||.|  ||..:..|..::
Yeast   156 KDFGTYLDSD--------------DQQFIKDRGIQSYFLLPSINDNIDEYG--NFLPSFIVQDKL 204

Human  3935 FNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK--------------------LSQD 3979
            ....:::.:...|.....|.|:|. |||...:.:|.|:|..                    :::.
Yeast   205 DIQFSKFNKSSSTVMNYPLPHNRK-DAVYFEVKIFRHIQKSNSIFSIGLTTVPYPYFRVPGMAKY 268

Human  3980 SSQIELLKELMDLQKDMVVMLLSML-EGNVV-------NGTI-----GKQMVDMLVESSNNVEMI 4031
            |...|...:|..........||..| ||:.|       .|||     ||:::|:    :.|:.:
Yeast   269 SIAYESTGKLRINNPFTASTLLPKLEEGDTVGFGYRYKTGTIFITHNGKKLMDV----TQNIGI- 328

Human  4032 LKFFDMFLKLKDLTSSDT----------------FKEYDPDGKGVISKRDFHKAMESHKHYTQSE 4080
                |:|:.:....::.|                |:|...:||.:...:|..:..:.|
Yeast   329 ----DLFIGIGAFNAAYTRTYTRDGLLEDPDNVSFREALSEGKDIEVAKDLQRVHDPH------- 382

Human  4081 TEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEH----------MP---NDTR 4132
                      ||::.:..:|.  ..|.....:||  ..:..|:.::          :|   |.|.
Yeast   383 ----------DESDEMTSDEV--ELHVNLGQVGF--VFIEANVKKYAFGSVYGQIGIPPAYNGTE 433

Human  4133 LQ--TFLELAESVLNYF---QPFLGRIEIM-GSAKRIERVYFEISESSRTQWEKPQVKESKRQFI 4191
            ::  |.|:..|.:...:   ..|.|.:::. ||:.||      .:::|:..|..
Yeast   434 IKKDTILQKGEELPPRYADTDNFFGSMKVKEGSSSRI------TAQTSKPLWSV----------- 481

Human  4192 FDVVNEGGEKEKMELFVNF-CEDTIFEMQLAAQISESD-----------LNERSANKEESEKERP 4244
                   |..|::.  .|| .|:.::...|....:.:|           .||.|...|:...:||
Yeast   482 -------GTYERIS--SNFDRENNVYHDSLETDDNNTDNNVNNNDENAGCNENSPLLEDDGNKRP 537

Human  4245 EEQG-PR 4250
            |... ||
Yeast   538 ENSNTPR 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RYR2	XP_006711865.1	Ins145_P3_rec	13..222	CDD:462572
		beta-trefoil_MIR_RyR2	230..413	CDD:467762
		RYDR_ITPR	455..648	CDD:460175
		SPRY1_RyR	654..805	CDD:240457
		RyR	862..951	CDD:460419
		RyR	976..1065	CDD:460419
		SPRY2_RyR	1086..1218	CDD:240458
		SPRY3_RyR	1412..1568	CDD:293937
		RYDR_ITPR	2135..2346	CDD:460175
		RyR	2711..2800	CDD:460419
		RyR	2831..2914	CDD:460419
		RIH_assoc	3849..3966	CDD:462482	24/119 (20%)
		EF-hand_7	4050..4105	CDD:463900	9/54 (17%)
		RR_TM4-6	4351..4617	CDD:461918
		Ion_trans	<4736..4896	CDD:459842
SSH4	NP_012798.1	SPRY	199..341	CDD:470632	29/151 (19%)