|
Human 1 MAD----GGEGEDEIQFLRTDDEVVLQCTATIHKE----QQKLCLAAEGFGNRLCFLESTSNSKN 57
||| ||..:|::.||||.|.|.|.|.|:.::: .:::||..||||||:|.||:.|: |:
Worm 1 MADKEEQGGGEQDDVSFLRTGDIVCLSCVASHNRDGVLGSERVCLCTEGFGNRMCTLENVSD-KD 64
Human 58 VPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQG-GGHRTLLYGHAILL 121
:|||:::|...::.:||:||||||::...:. |:|.| |||:|||||||:.|
Worm 65 IPPDIAMCMLYIDNALSMRALQEMMSADSDH--------------KSASGAGGHKTLLYGHAVQL 115
Human 122 RHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV 186
:|..|.|||.||| |.||.||||||||:||...||||||||||||||||||||||||||:|||||
Worm 116 KHVQSEMYLACLS-SCSSNDKLAFDVGVQETNEGEACWWTIHPASKQRSEGEKVRVGDDVILVSV 179
Human 187 SSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQ--GYLIGGDVLRLLHGHMDECLTVPS 249
::|||||::|..|.: |.|:|.||||::..:||||...: |:|.|.|||||.||: |||||:|.
Worm 180 ATERYLHMAYSKGYM-VIASFHQTLWNIQSVSSGSMRTRNMGFLFGNDVLRLFHGN-DECLTIPE 242
Human 250 GEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNL 314
......|...|.|||||....||||||:|.:|:.|.|:.:.|.|.||::|:|:|:||.:: |.::
Worm 243 NWSEHPQHNMVIYEGGAAVTQARSLWRVELIRMKWHGALVGWEQVFRIKHITSGRYLGVL-DNSV 306
Human 315 LLMDKEKADVKSTAFTFRSSKE-KLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVD 378
.|..|||||...|||....:|: |..:...||.:|||.:.|:||::..:||||.|.|||:||:.:
Worm 307 QLYHKEKADFDLTAFVMCQNKDPKKQMLDEKEEEGMGNATIRYGETNAFIQHVKTQLWLSYQTTE 371
Human 379 VKSVRMGSI-QRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKA 442
|....:|.: ::||:...:|||||..:...:..|||::|||||....:.|:|::|:|||..:...
Worm 372 VTKKGLGKVEEKKAVALKDGHMDDCYTFFMALEEESKSARVIRKCSSVLNKFLKGIDALQLEGNQ 436
Human 443 ST----VDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECID 503
|| ||| ..|...::|||.||..|::..:.|:|||.||||::||:||||||::|::|:.||
Worm 437 STDWTRVDL--NEVLKLMEDLIEYFAQPNDEQDFEEKQNHLRALRSRQDLFQEEGVLNMILDTID 499
Human 504 RLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGS--LDWLISRLERLE 566
:.....:...||.:.|.|....|:.|...||.|:||:|:||..|||||:.: ||||..||...:
Worm 500 KFSQMEALPDFAGLIGEETHVKWEQISTYLYLLVAAMIKGNHYNCAQFASAQRLDWLFGRLSNPQ 564
Human 567 ASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHL 631
::.|||:||:|||.|||||||:|.||||:|:||||:|.||:.||||||.|||..:|:||||:|:|
Worm 565 SAEGILDVLYCVLTESPEALNMINEGHIRSVISLLEKVGRDPKVLDVLSSLCEGNGMAVRSSQNL 629
Human 632 ICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVG 696
|...||||:||||||.:.:|||||.||:.|||.||||.::|||:|..|:|.|. :|.:..:||:|
Worm 630 ITQYLLPGKDLLLQTSMRDHVSSMMPNVMLGVVEGSALFRKWYFEAEVEHIET-MTKQTPYLRIG 693
Human 697 WASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDL 761
||::.|:.|:||.|::.|.||||||.:||||||..::.|..:|.| ...||...|||.|.:||
Worm 694 WANSVGFKPFPGSGDKMGCNGVGDDFYSYGFDGKSMYFGGKSRRV---GHKLLEKGDVIGCSIDL 755
Human 762 SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAV 826
:.|.|.|.:||..:.|.|:.|||||.||||:|.||.:..||:|||..|..::.||.|::...|||
Worm 756 TIPEIKFSVNGTYMSGSFKKFNIDGYFFPVMSLSAKVSCRFILGGNQGRLRYGPPTGFSAVVEAV 820
Human 827 LPKEKLKVEHSREYKQERTYTRDL-----LGP-TVSLTQAAFTPIPVDTSQIVLPPHLERIREKL 885
..:|::.....: .|| .|| |:......|.|.|:|.|...|..|...:.:|.
Worm 821 --NGELQITDCLSF-------GDLGKNIFSGPQTIFNNLEPFIPTPIDVSATQLNHHATEMHQKY 876
Human 886 AENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHV 950
|||:||||.|.||||||.||..|.:..|:||||.:|..|||.|:.||:.::|.|:||:.|||.|:
Worm 877 AENLHELWAMRKIELGWSYGETRSETSRKHPCLTKFEYLPETEKKYNILLALTTMKTIEALGYHL 941
Human 951 GISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQG 1015
...|... :::.::|..|:|..:||||.|:|...|:|....:.:.:.||.|.||:||:::|::|
Worm 942 ITEDPPC--RLRAVRLGPNFQQQNGYKPGPLDTHEIQLPAELQPLTEALARNTHNIWAKEKIKRG 1004
Human 1016 WTYGIQQ--DVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAE-V 1077
||:|:.: |...:|:|.||||..:|:|.|::|::|..|.:|.|..:|..||.|..:|...|| .
Worm 1005 WTFGLSEHVDATQKRSPHLVPYEQVDERIKQANRESAAENIRALQLFGIFLEPPAHEHDEVAEKE 1069
Human 1078 CSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKA 1142
.....:..|.:|||.||||..|:||||||.:|||.|::||...|..|:.:||:|:|::||||:..
Worm 1070 LRARKDNTRTYRAEATYAVCGGKWYFEFEILTAGYMKIGWMDIGSTPEIQLGADDRSYAFDGYLG 1134
Human 1143 QRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL 1207
::||||.|.||:.|:.||||||.:|:|:.|:.|:||||:|||.||||:||.:...|||.:|..:|
Worm 1135 RKWHQGAETYGKEWKIGDVVGCFLDLNDRTISFSLNGELLLDPSGSEMAFDNVVCGDGLVPAMTL 1199
Human 1208 GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPS--NHEHIEV 1270
|..|.||:|||:..::||:||.||||||||||.||..|.:.||.:|:||:|..:.: :...:||
Worm 1200 GSGQRGRLNFGQQSNSLKFFTTCGLQEGYEPFCVNMYRTMPMWFAKQLPRFEDISTLKSGSILEV 1264
Human 1271 TRIDGTIDSSPCLKVTQK---SFGSQNSNTDIMFYRLSMPIECAEVFSK-----TV--------- 1318
:||..|.:|.||||:.|| |.|..:....:.:.:||:|::|.:.|.| |:
Worm 1265 SRIPATGNSPPCLKILQKVTISEGGPSEKAKMEYIKLSLPVKCNDTFVKNKDKETIRRQLQEYKP 1329
Human 1319 ----------AGGLPG------------AGLFGPKNDLEDYD------------ADSD-----FE 1344
|.|:|. ..:.|.|:..|..| .|.| ..
Worm 1330 RSQSVVSQIRAPGIPKEFDDNKEKKGFLRSMLGSKDSHESDDDRRSRTNSKQPSVDGDEPPAVRR 1394
Human 1345 VLMKTAHG--HLVPD--RVDKDKEATKPE-----------FNNHKDY------AQEKPSRLKQRF 1388
.|::..|. .:..| |...|:.:.||: .|..|:: .:||.::|:|..
Worm 1395 SLLELPHDERQIAEDSMRDLNDRHSEKPKKGGLLSRLRDSSNTRKNFRDSDRRKEEKAAQLRQMK 1459
Human 1389 LLRRT----KPDYSTSHSARLTEDVLAD-----------------------------------DR 1414
...|: ..|.||..:.: :||||. :|
Worm 1460 ANSRSFDAGSLDTSTLPTGQ--KDVLASSEMPLSGPGRQLTIKRSSIKKNKKGKKAEIALEKMER 1522
Human 1415 D----------DYDFLMQ------------TSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGF 1457
: ..|.|.: ...|||.:||||||:|:.|||||:|:.:|.|:..|
Worm 1523 EKKGSIIPMDAQLDVLQEGDAHALVHHKDKVDEYYYGIRIFPGQDPSQVWVGWVTTQYHYYNVNF 1587
Human 1458 DLDR-VRTVTVTLGDEKGKVHESFAIDSLCGFGIKRSNCYMVCAGESMSPGQGRNN---NGLEIG 1518
|..: ||....:..| |....:|| ::..|||||...|.::......| :|..||
Worm 1588 DGSQGVRKCRFSEAD-----HHGTTVDS-----VQSQNCYMVNVSELLATTPDVANTKVSGTLIG 1642
Human 1519 CVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKS 1583
|::|.:.|.|:|.....:....:::||...||||.|...|:..:.||||||||...||||.:|||
Worm 1643 CIIDTSIGELSFQVGSTDTGIKFKLEPGAMLFPAAFVTPTATEILQFELGRIKYTFPLSAAMFKS 1707
Human 1584 EHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRS 1648
..|:.||.|||||.|:.:..|.|:|:||:.|:....::||.:||.|.|.||::.||::|||:::|
Worm 1708 CEKSLVPFCPPRLTVEQIESVYWARVPNETLRTTALKLSEVRGWSVLCNDPVRIMSVYIPEKDQS 1772
Human 1649 VDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYY 1713
:||||:.|..::|:||..||.||..:.:.|||:|||.||.|:||.|::|||::.|:.|.:|.|::
Worm 1773 LDILEMIEMPDMLEFHRQTLNLYCKLASHGNHKVAHTLCQHIDEDQIMYAIKSHYLSGPMRQGFH 1837
Human 1714 DLLIDIHLSSYATARLMMNNEYIVPMTE--ETKSITLFPDENKKHGLPGI-GLSTSLRPRMQFSS 1775
||||.:||.|:..||..|..||::|:.. :.|:: |.||...:: |.| |.|.|:..:|. |.
Worm 1838 DLLIGLHLMSHTAARNSMAKEYVIPLVPQLQIKNV-LDPDSESRY--PQITGESVSMLSQMA-SE 1898
Human 1776 P--SFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTL 1838
| ..||..:|.....|....:.||...::.|..|.....::.||.:||.....|.||.|||..|
Worm 1899 PVKKHVSREDEMKLLPPSVDFEALKKHVMESLQSATHHAVMNCRDLIGGDNTNHFEPLFKLFDQL 1963
Human 1839 LIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGL 1903
|::|:.::|:|:.:|:||.|..|.| ..|:.|.:| ||
Worm 1964 LVIGLINDEELECLLRLIHPQAFDE----NYETGTTQK-------------------------GL 1999
Human 1904 LQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALT 1968
.|::|.||||:|:..:|.:|||.|:|:|||::|||::.||.:||.:|..||.|:.|. :|..|..
Worm 2000 TQLELAEPVKIQLVSILDHLCDIQLRYRIESLVAFTEGFVGELQSDQCKRYMEIKQT-DMPPAEA 2063
Human 1969 ARKTKEFRSPPQEQINMLLNFK-------------DDKSECPCPEEIRDQLLDFHEDLMTHCGIE 2020
|:||||||.||:||:..||..| .|..:||..|.::.||.|| |.:.
Worm 2064 AKKTKEFRCPPKEQMFRLLMCKVKEERDPELMEEDADVDQCPMAEGLQQQLRDF-------CELL 2121
Human 2021 LDEDGSL-DGNSDLTIRGRLLSLVEK------------VTYLKKKQAEKPVESDSKKSSTLQQLI 2072
:.:.|:: :|:|| ..|:|:|. |..:.....|:.:|...|.:...:::|
Worm 2122 VGKIGNVKEGDSD-----DQLALIESEEGSWVDSFARIVVKVPPPVLEEGMEMQKKGTQNFREII 2181
Human 2073 SETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIR 2137
...:..|||...||...|:|.||.||.|||.||..:..|:.:||..:..:.:|..:.|..|.|||
Worm 2182 VTMLREWAQADFIESKSLIRNMFRLLLRQYSGIREIRDAMSQTYVFHERNEKDVTDFLVYLIQIR 2246
Human 2138 SLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVL---------GGGE 2193
.||:|:....||.::.|||..:|||::|:|||:|||.|.:||.||.:|:|:| .|.|
Worm 2247 ELLTVQFEHTEEAILKRGLWKLMNNRIFFQHPDLMRLLSVHENVMSIMMNILTAQQGTVEHEGDE 2311
Human 2194 SKEIT----FPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAA 2254
.||.. ..:||..|.||||||||.|||||||||:|||:||:|:::.||.|::|||.|||||.
Worm 2312 LKEKAPIKDASEMVVACSRFLCYFCRTSRQNQKAMFEHLSFLLDNATMLLARPSLRGSVPLDVAY 2376
Human 2255 ASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCN 2319
:|.||||||||||:|.:|:||..||:.||||....|::||||||||:|||||||:|||||.|:.|
Worm 2377 SSFMDNNELALALKEEELDKVAVYLSRCGLQPNSELITKGYPDIGWDPVEGERYIDFLRFCVWIN 2441
Human 2320 GESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAED----PSRDGPSPNS---- 2376
||:||||||:|:|||||||||.|.||:|| |.||.:|.:|||.::|| .:...||..|
Worm 2442 GENVEENANLVIRLLIRRPECLGVALKGE-GQGLFSAFKEAIALSEDIRLLENDSHPSLLSSGLL 2505
Human 2377 GSSKTLDTEEEE-DDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLG 2440
|.:.|..:::.| :|.|.:|.|.:.|||:|:|||.:|||:...|.||||:::|.|:||||||.|.
Worm 2506 GENPTYPSKDAEGEDYIDLGAATLDFYSSLVDLLAKCAPDPMAIQAGKGDSLRARAILRSLISLD 2570
Human 2441 DLVGVISIAFQMPTIA------------------------------------------------- 2456
||..::::.|.:|.:|
Worm 2571 DLGQILALRFTIPNLAAPSIEAVRRANAVQASHTQKAVMAHTFAMVASLASEVSNTRRSQTFTSG 2635
Human 2457 -------------------------------KDGN-----------------------VVEPDMS 2467
..|| :::...|
Worm 2636 TNLAKRGLPCVEEVDTDDSKSSDYASVHTSFSSGNELFAPKAEKEKVDVLKLNENKYPIIQRRRS 2700
Human 2468 A------------GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSAT 2520
: |..|:||.:::|||||||||:.||.|.|:||..||||||||..:|:.....:
Worm 2701 SRFNPIDNTGPLPGLLPNHKGSVLLFLDRVYGIDQQDMLFHVLEQSFLPDLRAATMMDSPRALES 2765
Human 2521 DMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLS 2585
|.|||||||||.:||||||..:..||..|||::|:|:.||||||:::..||||.|||::...|::
Worm 2766 DTALALNRYLCNSVLPLLTNHSHFFADAEHHSALLDATLHTVYRMNRLKSLTKNQRDAVSDFLVA 2830
Human 2586 ICGQLRPSMMQHLLRRLVFDVPLLNE-HAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELH 2649
|..:|.|:||..||::::.|:..:|: :..:||:|:|.|||||.||| |...::|.|||:|..
Worm 2831 ITRELPPAMMIKLLKKVITDILTMNDMNVLVPLRLITLHYERCGKYY---GSGNHYGVASEQEKR 2892
Human 2650 LSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDY-MESNYVSMMEKQSSMDSEGNFNP 2713
||..||..|||.|..:.|:.|||..||||::|:..|:.||| :.|....:..|: .:.||.:.|
Worm 2893 LSMLLFDAIFDTLGSRPYDPELFGKALPCMTAIGSAISPDYTLTSGLEDVRNKR--REEEGAWIP 2955
Human 2714 QPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEK 2778
:.||.|...|...||.....:|||.||.|:..||..||::|::||.::...|.:||:.||.:.||
Worm 2956 RTVDVSRCEINRDLEKMTELFAEHFHDSWASRKLEKGWVHGDLYSRANFTHPRLKPFALLKDFEK 3020
Human 2779 EIYRWPIKESLKTMLAWGWRIE-RTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVT 2842
..|:....|.||.::||.:..| ..|:.:..| :..|.:|.|| ...::|:.||:|::|
Worm 3021 SFYKERCSECLKALMAWNYSFEMMDRDANDRA--SAARTLSGTS------ISNFAPKPIDLSSMT 3077
Human 2843 LSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQ 2907
|.:|:...||.|||:.|.|||||...:|.:|||.....|||:|.||..|:.|||.:|.:||||||
Worm 3078 LEKDMVNAAEKMAEHSHLIWAKKVMNDLNTKGGFMPIPLVPWDLLTDFERRKDRFRASEILKFLQ 3142
Human 2908 INGYAVSRGFKD---------LELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSR-GKGE 2962
.:||.|:.. || .|.:..|:||||||:.|::||.|:::|...:........ .:..
Worm 3143 YHGYHVNCP-KDEQSQNDRLKSEGERTSVEKRFAYNLLEKLITYLEQASLKMKSVKPSQELTRRN 3206
Human 2963 HFPYE-QEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVR 3026
.|..| |::|||.||||||:..||..|:.|||..:| :...|.|||||||||.:|||:|..|:|
Worm 3207 SFKKEGQDVKFFEKVVLPLMHAYFNAHKNYFLEGSS--IVQTGTASNKEKEMVANLFCRLAALLR 3269
Human 3027 HRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQ-GQF 3090
.:...||:.|...|.||..|.|.||.||::|...:.|:::|..|.:|.|:||..::..||. ||:
Worm 3270 IKNRAFGSVAKITVKCLQGLTQALDLRTLVKVNSDIVRTSLLTFFNNCADDLYASVNELKDGGQY 3334
Human 3091 THTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYAL-GTSK 3154
:..|.|.........:....::|:|:::|.|:.::.||.||:|:|:|.:||:||.|||.: |.|.
Worm 3335 SLIRGQALKSWNSFEFANQMIVPVLTTMFAHLARNHFGTDLLLDDIQAACYKILDSLYMVTGLSS 3399
Human 3155 SI--------YVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNV 3211
|| ..|:.|..||:||||||..|||||||...:|.|.:|:. .||..: ::.:...:
Worm 3400 SISHRKSISGESEKHRPGLGQCLAAFASCFPVAFLEPEFNKSNKFSVL-AKSQDQ--SVQVQEML 3461
Human 3212 EDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAE---- 3272
:::..:||.||||:.::..:|.:...|:.:|:|.:|.||::||||:.|:..||:...::.:
Worm 3462 QNLSTHIPHLEKLLTDLETVANNNTMYSDVPNVYDVDLPLMCSYMAHWFSVGPDGKRDKEDQRAS 3526
Human 3273 -MCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKL 3336
:..|:::.:|:|.:...:||:|.|::||:...|:.|:..|:..||..|....::...||:.|:|
Worm 3527 VVQTTSVSCDHINRIFNALLKMIRNHVGIENAPWLCRVNFFAVQIIQNVTSDPVREFVLPIAERL 3591
Human 3337 KKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPE 3401
::.:.....||:|::... .|..|. .:.::...|.||.|||:|:|:::.|.:||:|||.|..|
Worm 3592 RRMSEKAYKEEEHMRTHP-DDADEG--TVAEDNARLVRDTYAFFPILMKYTDLHRAQWLKTPTWE 3653
Human 3402 AEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKG 3466
.:.::..||.:|..||:|.:|||||.|:|.|.|.:..:....|.|: .|||:: ||||.:|:|
Worm 3654 TDGVYENVAVIFRIWSQSQHFKREELNYVAQFEEDAAATGGGDMKT--GKAAIA--ERKKKRREG 3714
Human 3467 ------------------DRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTED 3513
|::: .|:::|.||||||:|||:....:.:::..:|.:|..|:||:
Worm 3715 QDKMKEYFDRNGRPIIKKDKHA--ASIVIACLKRLLPVGLNVFGGRELDIVQQSKEKFIQKETEE 3777
Human 3514 EVRDIIRSNIHLQGKLEDPAIR--WQMALYKDLPN---RTDDTSDPEKTVERVLDIANV--LFHL 3571
::|:.|:..:.:..| .||..: ||::||:.:.. |..|....:..:|::.::..| :.|
Worm 3778 KIREFIKGLLEIPVK-TDPTDKNAWQLSLYRKIGKSQMRGKDEMSQDAVIEKIFNMGQVSAILH- 3840
Human 3572 EQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEK 3636
..||||......|.|::|.||||||||||||.|||.:||||.:|.||..:.:
Worm 3841 -------------TTEHPQMQLSQAWKKVVSTQRKRAVVACFRMVPLYGIPRHRGINFFLPAFSR 3892
Human 3637 SWIETEEHYFEDKLIEDLAKPGAEPPE----------------EDEGTK----RVDPLHQLILLF 3681
.|:| ||...:|:||.|:.. |.|..| ..|.|| ..|||.|||..|
Worm 3893 LWME-EEDAGQDQLIADICS-GVEEEEGPRIEIIMEEGVPIVASSEDTKEKETNPDPLKQLIRCF 3955
Human 3682 SRTALTEK---CKLEEDFLYMAYADIMAKSCHDEEDD--DGEEEVKSFEVTGSQRSKEKEMEKQK 3741
.|.|.:|: ..:.||.||:.:||:||||.|.||:| |||| |......||.:.|.
Worm 3956 QRAATSEETAASAIHEDSLYIRFADVMAKSIHIEEEDGEDGEE--------GEIDQAAKEEQSQA 4012
Human 3742 LLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVG 3806
|..:||.|..||||.|.|..:|||.||...|||.||:|||.:|:|||..:|:.:::||:.||||.
Worm 4013 LRGEQAVLASRGAAIMCLMYLSASGGEPNEMVAQTLQLGIHLLSGGNVEIQKMLIEYLQLKKDVR 4077
Human 3807 FFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGE-KVLQDDEFTCDLFRFLQLLCEGHNS 3870
||.|:||||..||||:|..||||.|||||||..|..||: :.|.|.:|||.|||||||.|||||.
Worm 4078 FFTSMAGLMNKCSVLNLEMFERQIKAEGLGMGAELASGDNQNLNDADFTCSLFRFLQLTCEGHNL 4142
Human 3871 DFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVF 3935
:||||||||.|:.|:||:|..|||||||:|||:.||||:||.|:||||.|:..|.:||||..|||
Worm 4143 EFQNYLRTQPGHTTSVNLINCTVDYLLRLQESVMDFYWHYSSKEVIDEGGKEYFLRAIQVCSQVF 4207
Human 3936 NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVML 4000
|||||.|||||.|||.:||:||||||:.||..:||||..||.::|:|:|||:|.::|||||:|::
Worm 4208 NTLTESIQGPCVGNQMTLANSRLWDAINGFFFLFAHMMEKLYKNSTQLELLREFLNLQKDMIVLM 4272
Human 4001 LSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRD 4065
||||||||:||:|||||||.||||..:||.||||.||||||||||:|..|:::|.:..|.||.::
Worm 4273 LSMLEGNVLNGSIGKQMVDALVESQPSVEKILKFSDMFLKLKDLTTSQAFQDFDTNQDGWISPKE 4337
Human 4066 FHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPND 4130
|.:||||.|.||..:..:|:.|.:.:.:..:||.||.:|||.||:|||||:||||.||.||:.||
Worm 4338 FQRAMESQKMYTVEDITYLMMCTDVNNDGKVDYMEFTERFHNPARDIGFNLAVLLVNLKEHITND 4402
Human 4131 TRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVV 4195
.||:..:|.|:::|.||.|||||||||||:||:|::||||.||...||.|.|:::||..|:|:|:
Worm 4403 PRLEKIIEKAQTLLEYFDPFLGRIEIMGSSKRVEKIYFEIQESWLEQWGKQQIRDSKNSFLFNVL 4467
Human 4196 -NEGGEKEKMELFVNFCEDTIFEMQLAAQISESD--------LNERSANKEESEKERPEEQGPRM 4251
::||::.|:|.|:|||||||||||.||.||..| :.:|....:::..:...|.....
Worm 4468 QDDGGDQGKLEAFINFCEDTIFEMQHAAAISSGDSDTKMERAIKQRDYFLQQTSADHISETFKSG 4532
Human 4252 AFFSILTVRSALFALR-YNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSY--------WS 4307
..:.| ||..||. .||.|.||.:| ..|::|:...::.|....: |:
Worm 4533 YNYGI----SAASALSPQNISTTMRNVS--------SSVRQMSWTQLLYAVIILFIRAGLAIGWA 4585
Human 4308 IFMTLLHFVASVFR-GFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKP 4371
.::.|: ::|| |:|....| :|.....:|.|:..
Worm 4586 GYLLLM----TIFRFGYFLTTSS----------------------------EEEEAARQEKEQAK 4618
Human 4372 LEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPH-NPNAGLSDLMSNPVPMPEVQE 4435
:....||.:...::|. ..|.:....||:.:..: | |.|: |.|.: |...||..|
Worm 4619 MNNEHPSFNPPIIQEF-HHSHVGVTAFGVGMNAD--------HLNVNS-LPDFV--PPERPETPE 4671
Human 4436 KFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTH------RYGEPEVP 4494
...||||...:|| .|..:......|.....|..|..::.||.:. :| ||::.
Worm 4672 -----TVLEEEKPLNQET--SPPTSPTSPASKAPSIYESIGAPQMVQLQSEADFQQGQY-EPKIA 4728
Human 4495 ESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSEN 4559
||...|. :..:||..||||..:..:.|::||.||.||||::|.. |.:||
Worm 4729 ESNSTKS----RGSILNMLARNFKTIEKITLYLAFFINVILLFHRVDI------------SHAEN 4777
Human 4560 AKVTS--------LDSSSHRIIAVHYVLEESSGYM-EPTLRILAILHTVISFFCIIGYYCLKVPL 4615
|:..| |:|.....:...||..|.:|:| ...|..:::||...||..::.:|.||:||
Worm 4778 AEAASEGDDDEDALESIFITGMQFPYVEYEITGWMLAQILYWISVLHLSTSFALLVSFYQLKIPL 4842
Human 4616 VIFKREKEVARKLEFDGLYITEQPSE-----DDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKY 4675
:.||||||:||||.|||.:|||:.|| |......||:|::.:|||..||||||:||...|:
Worm 4843 ITFKREKEIARKLMFDGCWITEEDSEELGIVDTFMWYLDRIVVSAKSFPMMYWDKFVRRKTRSKF 4907
Human 4676 GEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWK-LGVVFTDNSFLY 4739
.:....:.::.:||.:|.:.| :|.|.:|..|. :||:.|:..|||
Worm 4908 KDQVDEETLTSILGEEKMSTD--------------------SSYDYRYSCWLWIGVILTNGQFLY 4952
Human 4740 LAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVA 4803
...|:..|..|.: :.||:|.||:|:.:.|..|:.||.|||||.:||:||:.:..||||||||:|
Worm 4953 RVGYLLCSACGVFLSPFFYAFHLIDVVLSFPMLKAILQSVTHNLQQLILTIMMTLVVVYLYTVIA 5017
Human 4804 FNFFRKFY-NKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT 4867
|||||||| .:.|:|:.||.||.:||||:::|.|.|||||||||||:|.|.||:.|..|:.:||:
Worm 5018 FNFFRKFYVQEGEEGEEPDRKCHNMLTCFIYHFYAGVRAGGGIGDELESPYGDDLEYPRMFYDIS 5082
Human 4868 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHN 4932
||||||:|||||:||||||||||||||||...|.:|:.||||.||.:.||.:|.|||.||.:|||
Worm 5083 FFFFVIIILLAIMQGLIIDAFGELRDQQESATEKLESSCFICDIGKETFDRMPRGFEIHTTKEHN 5147
Human 4933 LANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQL 4984
.|||||||.:|:||||||:||||:||.:.|..|.|:|||.|:||.|||||||
Worm 5148 FANYLFFLQHLVNKDETEYTGQETYVREKYDNRDWDFFPVGECFVKQYEDQL 5199
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