DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RYK and Drl-2

DIOPT Version :9

Sequence 1:	NP_001005861.1	Gene:	RYK / 6259	HGNCID:	10481	Length:	610	Species:	Homo sapiens
Sequence 2:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	216/695 - (31%)
Similarity:	340/695 - (48%)	Gaps:	164/695 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    33 LALLPLLPAPGAAAAPAPRPPELQSASAGPSVS----LYLSEDEVRRLIGLDAELYYVRNDLISH 93
            :.||||         .:|.|..|...:...|||    :::|..||.:|:||:|:|:||....|:.
  Fly     1 MELLPL---------KSPLPILLLCLTISTSVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINT 56

Human    94 YALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQV-----DNVLAMDMPQVNISVQGEVPRTLSVF 153
            ||:.|::.||::.:.|.|:|  :|.:.|.|.:.:     ::..|:..|.::|..:|.||:.:..|
  Fly    57 YAMHFTVPVPADVHELEFSW--QSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESF 119

Human   154 RVELSCTGKVDSEVMILMQLNLTVNSSKNF--TVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYD 216
            .|.|.|||  ::.:.:.:.:|:.|.:...|  |.|:|||.|:|.|.:..      :.|.|..
  Fly   120 LVYLPCTG--NASLQMPVNVNMVVRAPPRFNDTRLHFKRNKICAKGISP------EPNQSPA--- 173

Human   217 PVHAAPTTSTRVFYISVGVCC-AVIFLVAIILAVLHLHSMKRIELD------------------- 261
            |.| ||:....:  :|...|. .::..|.::.:::::.:.|::..|
  Fly   174 PAH-APSQGPAL--LSAAACALGLVLAVGLVASMMYVRARKQLRQDSLHTSFTTAAYGSHQNVFI 235

Human   262 --------------------------DS------------------------------------- 263
                                      ||
  Fly   236 RLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYS 300

Human   264 ---------ISASSSSQGLSQP-STQTTQYLRADTPNNATPITSSL----GYPT-------LRIE 307
                     ||..:||| |:|| |..|.:.:|::...|.|..:.||    |.||       ...|
  Fly   301 KPESICPSRISYYASSQ-LTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGE 364

Human   308 KND--LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK 370
            |.:  ||.:|      .|:..|:|.|     ::::|||||||:.|.|      .:..:|.||||.
  Fly   365 KGNQRLRRIT------SVQPGALSYE-----ELVKEGTFGRIYAGKL------GESCEALVKTVI 412

Human   371 DQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEAN 435
            |.||..||..:|.::..|.|:.|:::|.......|....|.:..|:.:.||||::|::.:    .
  Fly   413 DGASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSR----E 473

Human   436 NPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHC 500
            :..|:|.:.||...:.|..|::||....::|||:|.|||.:|:...|||.|:||||||||.||.|
  Fly   474 SSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDC 538

Human   501 LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
            ||||||||::|::||||....:::..||||.|||.|||:||.|.|:.::|.||:..||..|:|:.
  Fly   539 LGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLE 603

Human   566 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 610
            ||:|||||.|.||.|||..:.::||...||:..|.:|||.||.|:
  Fly   604 QPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYK	NP_001005861.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		WIF	63..196	CDD:128745	47/143 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		9/24 (38%)
		PTK_Ryk	326..606	CDD:270639	121/279 (43%)
		Pkinase_Tyr	333..599	CDD:285015	114/265 (43%)
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	37/122 (30%)
		PTK_Ryk	373..644	CDD:270639	123/291 (42%)
		STYKc	389..637	CDD:214568	114/257 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7992
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68287
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.870