Protein Alignment RTN2 and rtn2a

DIOPT Version :10

• Sequence 1: XP_054177679.1
• Gene: RTN2 / 6253
• HGNCID: 10468
• Length: 662
• Species: Homo sapiens
• Sequence 2: XP_005157528.1
• Gene: rtn2a / 569502
• ZFINID: ZDB-GENE-060420-1
• Length: 451
• Species: Danio rerio
• Alignment Length: 554
• Identity: 168/554 - (30%)
• Similarity: 237/554 - (42%)
• Gaps: 144/554 - (25%)

Human   134 TASSTPDST----EGGNDDSDFRELHTAREFSEEDEEETTSQD--------WGTPR----ELTFS 182
            |.:||||||    :|||::|||.||.||||:|:||:|.....|        |||||    |||||
Zfish    15 TVNSTPDSTPPCSDGGNEESDFPELQTAREWSDEDDEGLEDDDACLSSSSVWGTPRQNSFELTFS 79

Human   183 YIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTA 247
            ||||....|: .||||..||..|:....|..|.        |:||                  |.
Zfish    80 YIAFSESDGT-SRRDSGRRRTGPRSGRGSLHRT--------DTLE------------------TQ 117

Human   248 PPSERPLED----LRLRLDHLGWVARGTGSGEDSS---TSSSTPLEDEEPQEPNRLETGEAGEEL 305
            ||.:.|..:    ..|.||       |.|..|:.|   |..:..||..:.::....:|.|....:
Zfish   118 PPPDSPAVEWDPHAFLTLD-------GEGDVEEESQMWTVETQSLETLQDKDTGTWDTAEKISGI 175

Human   306 DLRLRLAQPSSPEVLTPQL---SPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREP 367
            ............::..|||   .|...|....|...:.:..:......|..:||:
Zfish   176 QSYNLTCSHQEEQITVPQLPASDPAVATETTATLQTAEASHTMPPSVGPNTQEEQ---------- 230

Human   368 VRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLWTAIGWVQRGPTPPTP 432
                                  |..:|..:            |.||           .|||....
Zfish   231 ----------------------TCKQWFSS------------LSLS-----------EGPTIHIQ 250

Human   433 VLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVA 497
            :                           .|.||:||||...:|:|.|||:|:||.|...||::|.
Zfish   251 I---------------------------AVMDLVYWKDMERTGMVLTGLVVALLSLFQLSIITVV 288

Human   498 AHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQ 562
            :.|:|.:||.|||:|:|.|:|..:..|||.:|||:|||:|::|:.|:.|....:......||...
Zfish   289 STLSLAILCFTISVRIYYKLLHVLQLGDGVHPFQSYLDLDISLSGEEAEHCLQRAIVLSCSALET 353

Human   563 LRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVT 627
            ||:...|.:|..|||..||.|::||:|.:.|||||:|:|||.:|::||.|.:||.::|..:..|.
Zfish   354 LRNLIFVGNLFSSLKFWLLMYVVTFLGNLCNGLTLIIIGVIAVFSVPLFYTRHQDKVDSCIVAVQ 418

Human   628 NQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKA 661
            .|:.:||........|.|.......  .|:|.||
Zfish   419 AQIDNIKDFFYRLTQGGGPPPDPTP--GGAKPKA 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	XP_054177679.1	PRK07764	<99..304	CDD:236090	67/192 (35%)
		Reticulon	462..626	CDD:460562	74/163 (45%)
rtn2a	XP_005157528.1	Reticulon	253..414	CDD:460562	74/160 (46%)