DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RTN2 and rtn2b

DIOPT Version :9

Sequence 1:	NP_005610.1	Gene:	RTN2 / 6253	HGNCID:	10468	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001025130.1	Gene:	rtn2b / 562639	ZFINID:	ZDB-GENE-060331-95	Length:	208	Species:	Danio rerio

Alignment Length:	208	Identity:	78/208 - (37%)
Similarity:	123/208 - (59%)	Gaps:	5/208 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   341 MGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVH 405
            |.|||.||:||::..|:|||||||:|.|..|...|.:::.::|.|.::..|:.:|:..|.:....
Zfish     1 MASKVLDLIYWRNLATTGVVFTGLVVGLASLFQLSAITILSNLGLSIMAFTLPVRLLYKAMTVTR 65

Human   406 RGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTF 470
            ..||::|||:|||.|.|||.|.|.|::.|:...:.:|.::|:..|.::.::||:|..:..|:||:
Zfish    66 LNDGSHPFQSYLDEDHTLTDEDTVRMAEQMVLLIATAVSELKRLFFIDSIMDSVKFIVFLYLLTY 130

Human   471 VGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKI-----RAKIPGTGAL 530
            ||...|||||::.|||..|::||||:..|.:||:.:..|...:..|...:     .||.|...|.
Zfish   131 VGVQANGLTLVMSGVICAFSLPLLYKLQQERIDKIIKAVQLLVEKITEMVDLVVSLAKPPPAPAP 195

Human   531 ASAAAAVSGSKAK 543
            ..|.|.....|.|
Zfish   196 PPAPALKHKQKTK 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..250
		Reticulon	345..509	CDD:280592	65/163 (40%)
rtn2b	NP_001025130.1	Reticulon	5..167	CDD:280592	65/161 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	7	7.200