DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RTN2 and rtn1

DIOPT Version :9

Sequence 1:	NP_005610.1	Gene:	RTN2 / 6253	HGNCID:	10468	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001018789.2	Gene:	rtn1 / 3361269	PomBaseID:	SPBC31A8.01c	Length:	308	Species:	Schizosaccharomyces pombe

Alignment Length:	252	Identity:	46/252 - (18%)
Similarity:	86/252 - (34%)	Gaps:	47/252 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   294 ELSPPLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSG 358
            |.|.|:....| ...|.....|.|.....:..:.:.:..|.:|      :.:..:|.||:|..|
pombe    83 ETSSPVCPVSG-AHGGADKKCPALEAGCPFTNTTKQNVDPEIS------NALWSVLTWKNTSCS- 139

Human   359 VVFTGLMVSLLCLLH------------------FSIVSVAAHLALLLLCGTISLRVYRKVLQAVH 405
              |:.|| |:|.|::                  |.|.|:.....|....|              .
pombe   140 --FSTLM-SILALVYVPSWINLPRLFFRTFRYVFLITSIIEFGGLFASNG--------------K 187

Human   406 RGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTF 470
            ||..::...:|:..|    .:..:|:.:.|.........|.:.....|..:.:...::..:|..|
pombe   188 RGVLSHFRSSYITCD----SKALDRIVNSIVDIFNVMLIQFQRILFAESPILTFTASVAAFIEFF 248

Human   471 VGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGT 527
            :....:..:|.:..|:..|.:|.||..::..|...|..:......:|.:....|..|
pombe   249 LSGFLSYKSLFVWNVLFAFILPRLYVCNERSIKHLVASLERSGDKLKKQATETINTT 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..250
		Reticulon	345..509	CDD:280592	34/181 (19%)
rtn1	NP_001018789.2	Reticulon	130..285	CDD:280592	33/176 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900