Protein Alignment RTN2 and ret-1

DIOPT Version :9

• Sequence 1: NP_005610.1
• Gene: RTN2 / 6253
• HGNCID: 10468
• Length: 545
• Species: Homo sapiens
• Sequence 2: NP_001123026.1
• Gene: ret-1 / 179981
• WormBaseID: WBGene00004336
• Length: 3303
• Species: Caenorhabditis elegans
• Alignment Length: 592
• Identity: 130/592 - (21%)
• Similarity: 230/592 - (38%)
• Gaps: 106/592 - (17%)

Human     6 PVFAHCKEAPSTASSTPDSTEGGNDDS-DFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAF 69
            ||....:::...:..:.|...|..||. .|.|.:.|.|.:.:..::.:|.              .
 Worm  2760 PVHDPMQKSVFGSLGSDDMKPGSQDDGFVFIERNEANEATLKKNQKMSSH--------------H 2810

Human    70 DGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSL-SQSPEPGRRGDPDTAPPS 133
            :.|:......|:.     |....:..|..:..:..:.|::||.... .|:.:.|.....:.....
 Worm  2811 NDVIEKNYFNDNA-----PTAALLESPIAEEARKLVQDAVESASEYKKQAVDSGDEIGRELLDNV 2870

Human   134 ERPLEDLRLRL-DHLGWVARGTGSGEDSSTSSST-----PLEDEEPQE--PNRLETGE------- 183
            |:.:|.::..: |.|.....|.|.....:..::.     ..|.:.|:.  |.::||.|
 Worm  2871 EQKIEQVKEPIVDSLHKAYDGVGDFVHETVPNAVDDFVREAEKQLPESPVPEKIETPEPLVDIHD 2935

Human   184 ----AGEELDLRLRLAQPSSPEVLTPQLSP-GSGTPQAG--TPSPSRSRDSNSGPEEPLLEEEEK 241
                ..:|:|..||  :..:|...|..::| ....||.|  ||....:.....|| ..:.||.||
 Worm  2936 TVDKVHDEVDNFLR--REPTPPFETDDVAPLSDDKPQFGNQTPEEDETTFDRKGP-LTIPEEVEK 2997

Human   242 QWGPLEREPVRGQCLDSTDQLEFTVEPRLLG------TAMEWLKTSLLLA--VYKTVPILELSPP 298
                  ....:...||..|.|..:......|      .|:|.|....:..  .::|||
 Worm  2998 ------AAAAQNNDLDDFDPLVTSNTGAAFGAAVGAAAAVESLTEEEMFGHQKFETVP------- 3049

Human   299 LWTAIGWVQRGPTPPTPVLRVLLKWA----------KSPRSSGVPSLSLGADMGSK--------- 344
                     |.||||..:....:|.:          ..|.|   |..|:....|..
 Worm  3050 ---------RPPTPPKDISDEDVKPSTVNLGPSHHHSHPSS---PHHSILKHHGDAWIDFKTVPP 3102

Human   345 -VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLR----VYRKVLQAV 404
             |.|::||:|.:.|.:|.:..::.|..|..:.:::|..:..||.|......|    |::||...:
 Worm  3103 CVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRSIFSVFKKVEAQI 3167

Human   405 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILT 469
            .:.|..:||...|..||||.:|:....:..........|.:|:....||..::|:|..|:.:.||
 Worm  3168 KKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLT 3232

Human   470 FVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAA 534
            ::.:.|:|.||.|||::|:|::|.:|..:|..||.::..::..|.:::..|..|:|   .|.||.
 Worm  3233 YIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLP---FLRSAP 3294

Human   535 AAVSGSK 541
            .|....|
 Worm  3295 VAAEEKK 3301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..183		31/186 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..250		14/53 (26%)
		Reticulon	345..509	CDD:280592	49/167 (29%)
ret-1	NP_001123026.1	PRK01558	<2835..>2918	CDD:304934	13/82 (16%)
		Reticulon	3104..3272	CDD:280592	49/167 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I3848
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm16478
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.040