Protein Alignment RTN2 and ret-1

DIOPT Version :10

• Sequence 1: XP_054177679.1
• Gene: RTN2 / 6253
• HGNCID: 10468
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_001123026.1
• Gene: ret-1 / 179981
• WormBaseID: WBGene00004336
• Length: 3303
• Species: Caenorhabditis elegans
• Alignment Length: 730
• Identity: 156/730 - (21%)
• Similarity: 266/730 - (36%)
• Gaps: 192/730 - (26%)

Human    53 TAVQPP---------VSTRGQRERRRSSALKKARRS-------------ASRTPSGSL------G 89
            |::..|         :|:.|.|::.| :|::..|:.             :|..||..|      .
 Worm  2640 TSIDDPSIRRDSFSSISSFGDRQKFR-TAIENIRQDLLPFQSSVSQYLRSSPNPSQQLLVTNLSM 2703

Human    90 SGPSSWSTWPGKWRAPKRAARAPPW----PSRTANKAQPGGRPEEAPSTASSTPDSTEGGNDDSD 150
            ..||..|            ..|||.    .::...|.|...||            |.||..|.|.
 Worm  2704 DSPSDLS------------PNAPPVGFENTAQFLEKLQQEDRP------------SAEGSIDSSG 2744

Human   151 FREL-HTA-REFSE----------------EDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRD 197
            |.:: |.. .||:.                .|:.:..|||.|      |.:|.      .....:
 Worm  2745 FEKVDHEGLDEFAAPPVHDPMQKSVFGSLGSDDMKPGSQDDG------FVFIE------RNEANE 2797

Human   198 STARRPR-------------------PQGRSVSEPRDQHPQPSLGDSLESIPSL-SQSPEPGRRG 242
            :|.::.:                   |....:..|..:..:..:.|::||.... .|:.:.|...
 Worm  2798 ATLKKNQKMSSHHNDVIEKNYFNDNAPTAALLESPIAEEARKLVQDAVESASEYKKQAVDSGDEI 2862

Human   243 DPDTAPPSERPLEDLRLRL-DHLGWVARGTGSGEDSSTSSST-----PLEDEEPQE--PNRLETG 299
            ..:.....|:.:|.::..: |.|.....|.|.....:..::.     ..|.:.|:.  |.::||.
 Worm  2863 GRELLDNVEQKIEQVKEPIVDSLHKAYDGVGDFVHETVPNAVDDFVREAEKQLPESPVPEKIETP 2927

Human   300 E-----------AGEELDLRLRLAQPSSPEVLTPQLSP-GSGTPQAG--TPSPSRSRDSNSGPEE 350
            |           ..:|:|..||  :..:|...|..::| ....||.|  ||....:.....|| .
 Worm  2928 EPLVDIHDTVDKVHDEVDNFLR--REPTPPFETDDVAPLSDDKPQFGNQTPEEDETTFDRKGP-L 2989

Human   351 PLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLG------TAMEWLKTSLLLA--VYKTV 407
            .:.||.||      ....:...||..|.|..:......|      .|:|.|....:..  .::||
 Worm  2990 TIPEEVEK------AAAAQNNDLDDFDPLVTSNTGAAFGAAVGAAAAVESLTEEEMFGHQKFETV 3048

Human   408 PILELSPPLWTAIGWVQRGPTPPTPVLRVLLKWA----------KSPRSSGVPSLSLGADMGSK- 461
            |                |.||||..:....:|.:          ..|.|   |..|:....|..
 Worm  3049 P----------------RPPTPPKDISDEDVKPSTVNLGPSHHHSHPSS---PHHSILKHHGDAW 3094

Human   462 ---------VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLR----V 513
                     |.|::||:|.:.|.:|.:..::.|..|..:.:::|..:..||.|......|    |
 Worm  3095 IDFKTVPPCVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRSIFSV 3159

Human   514 YRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKL 578
            ::||...:.:.|..:||...|..||||.:|:....:..........|.:|:....||..::|:|.
 Worm  3160 FKKVEAQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKF 3224

Human   579 ALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 643
            .|:.:.||::.:.|:|.||.|||::|:|::|.:|..:|..||.::..::..|.:::..|..|:|
 Worm  3225 GLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLP- 3288

Human   644 TGALASAAAAVSGSK 658
              .|.||..|....|
 Worm  3289 --FLRSAPVAAEEKK 3301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	XP_054177679.1	PRK07764	<99..304	CDD:236090	43/265 (16%)
		Reticulon	462..626	CDD:460562	49/167 (29%)
ret-1	NP_001123026.1	rad2	<1289..>1749	CDD:273166
		PRK12323	<1871..2286	CDD:481241
		PRK01558	<2835..>2918	CDD:304934	13/82 (16%)
		Reticulon	3104..3272	CDD:460562	49/167 (29%)