DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RTN2 and rtn2

DIOPT Version :9

Sequence 1:	NP_005610.1	Gene:	RTN2 / 6253	HGNCID:	10468	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001107739.1	Gene:	rtn2 / 100135745	XenbaseID:	XB-GENE-941644	Length:	321	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	156/529 - (29%)
Similarity:	216/529 - (40%)	Gaps:	221/529 - (41%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGQVLPVFAHCKEAPSTASSTPDS--TEGGNDDSDFRELHTAREFSEEDEEETTSQDW--GTPRE 61
            ||.||. |.|||:|||||||||||  .||..|||...|::.                |  .:|.|
Frog     1 MGHVLS-FTHCKDAPSTASSTPDSCPPEGEEDDSPVTEVNF----------------WPLPSPHE 48

Human    62 LTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGD 126
            .|||||    .:||
Frog    49 PTFSYI----TIGS--------------------------------------------------- 58

Human   127 PDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLR 191
              |||.|..|   :|.|        ||.|
Frog    59 --TAPLSRPP---VRAR--------RGLG------------------------------------ 74

Human   192 LRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCL 256
                                           :|| .::.|.|   |.|||:
Frog    75 -------------------------------QSR-VHAAPRE---ETEEKE-------------- 90

Human   257 DSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPP-LWTAIGWVQRGPTPPTPVLRVL 320
                              ::.:.|.:||.  ||..:.:|||| :...:.:|.: |.|...|.|.
Frog    91 ------------------VKDVVTYVLLE--KTCQLKKLSPPHVQEEVVFVAK-PQPQLEVFRA- 133

Human   321 LKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLAL 385
                                    |.|||||:|...|....||:.:|||||..||::||.|:..|
Frog   134 ------------------------VKDLLYWRDILLSAGCLTGVTLSLLCLSQFSVISVFAYGCL 174

Human   386 LLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFF 450
            ::|..|::||:|.|:|.|:.||:||||||.|||.||.||.:|.|.::.::.|.:.:....||..|
Frog   175 IILSVTLTLRLYTKLLHALKRGNGANPFQYYLDADLKLTTKQAEEITARVLSLLSTTICTLRSLF 239

Human   451 LVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSH 515
            |||:|.||||..::.|:||:|||:|||:|:|:|.|||.||.|:||:|||.|:|.||.||:.: :.
Frog   240 LVEELKDSLKFLVIIYLLTYVGAVFNGITVLLLCVIGAFTFPILYKQHQTQVDHYVSLVSKKXNA 304

Human   516 IKAKIRAKI 524
            .::||:..:
Frog   305 FRSKIQGTV 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183		45/185 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..250		8/50 (16%)
		Reticulon	345..509	CDD:280592	85/163 (52%)
rtn2	NP_001107739.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		24/35 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..85		10/101 (10%)
		Reticulon	134..298	CDD:280592	85/163 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I17501
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32180
Inparanoid	1	1.050	188	1.000	Inparanoid score	I12173
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011511at2759
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm55066
Panther	1	1.100	-	-	LDO	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	1	1.000	-	-		X10451
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.100