Protein Alignment RSU1 and ics

DIOPT Version :10

• Sequence 1: NP_036557.1
• Gene: RSU1 / 6251
• HGNCID: 10464
• Length: 277
• Species: Homo sapiens
• Sequence 2: NP_609665.2
• Gene: ics / 34774
• FlyBaseID: FBgn0028546
• Length: 283
• Species: Drosophila melanogaster
• Alignment Length: 272
• Identity: 159/272 - (58%)
• Similarity: 211/272 - (77%)
• Gaps: 6/272 - (2%)

Human     1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNL 65
            |||: ||:::|:||.:.||:|::|:|:|:..::.|||.:|:||:|.|||||::::.|.||.|.||
  Fly    12 MSKA-KKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNL 75

Human    66 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNF 130
            |:||..|||:.|||..:||:.||:.||:.:|||..||||||:.|.||||||:||||:|..|||||
  Fly    76 EILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNF 140

Human   131 FYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
            |.:.|||||||.|||||.:|.::|:|..||||.||||||:.||:|:|:|.:|:|||||.|||.||
  Fly   141 FGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVL 205

Human   196 PPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQA---NPEPP 257
            |||:..|||...|.|.|.|.||||.|||:|:.||:|||.:|:::||||.:|.||:||   .|.||
  Fly   206 PPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPP 270

Human   258 KKNNDKSKKISR 269
            |.  |||||.||
  Fly   271 KA--DKSKKASR 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RSU1	NP_036557.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		11/22 (50%)
		leucine-rich repeat	19..41	CDD:275380	8/21 (38%)
		LRR	<34..>205	CDD:443914	106/170 (62%)
		LRR 1	41..63		11/21 (52%)
		leucine-rich repeat	42..64	CDD:275380	12/21 (57%)
		LRR 2	64..85		12/20 (60%)
		leucine-rich repeat	65..87	CDD:275380	12/21 (57%)
		LRR 3	87..109		13/21 (62%)
		leucine-rich repeat	88..110	CDD:275380	12/21 (57%)
		LRR 4	110..133		17/22 (77%)
		leucine-rich repeat	111..135	CDD:275380	17/23 (74%)
		LRR 5	135..156		14/20 (70%)
		leucine-rich repeat	136..158	CDD:275380	14/21 (67%)
		LRR 6	158..179		14/20 (70%)
		leucine-rich repeat	159..181	CDD:275380	15/21 (71%)
		LRR 7	181..202		14/20 (70%)
		leucine-rich repeat	182..207	CDD:275380	17/24 (71%)
		leucine-rich repeat	208..227	CDD:275380	12/18 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..277		13/23 (57%)
ics	NP_609665.2	leucine-rich repeat	29..51	CDD:275380	8/21 (38%)
		LRR	<31..>208	CDD:443914	106/176 (60%)
		leucine-rich repeat	52..84	CDD:275380	18/31 (58%)
		leucine-rich repeat	98..120	CDD:275380	12/21 (57%)
		leucine-rich repeat	121..145	CDD:275380	17/23 (74%)
		leucine-rich repeat	146..168	CDD:275380	14/21 (67%)
		leucine-rich repeat	169..191	CDD:275380	15/21 (71%)