Protein Alignment CLIP1 and CLIP-190

DIOPT Version :9

• Sequence 1: NP_001376220.1
• Gene: CLIP1 / 6249
• HGNCID: 10461
• Length: 2148
• Species: Homo sapiens
• Sequence 2: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Alignment Length: 2285
• Identity: 575/2285 - (25%)
• Similarity: 937/2285 - (41%)
• Gaps: 682/2285 - (29%)

Human     5 KPSGLKAPTKILKPGSTAL--------KTPTAVVAPVEKTI----SSEKASSTPSSETQEEF--- 54
            :||.:|||:.....||.:.        .||.:...|.|.|.    |.:..||..|:.|....
  Fly    52 QPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVL 116

Human    55 ---VDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKG 116
               .:.|.:|:|||:.|.:||.|.|:|:|.||.|:|||:|||||.|||||.|:|.|||||||.:|
  Fly   117 TANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRG 181

Human   117 IFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSA 181
            ||:|.::||             |.|.:.|.:|    |:.:..|||.....:
  Fly   182 IFSRLTRLT-------------TYPLAGAQTP----TSPLAKSSPDRSRTV-------------- 215

Human   182 TPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVG---GTKAGVVRFLGETDFAKGEWCG 243
                   :.|||...|.|...|.  .|:..:.:||||:|.   |::.|::|:||||.||.|.|||
  Fly   216 -------SPTASIRSSMLRSPGI--GGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCG 271

Human   244 VELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLK 308
            ||||||.|||||.|...|||:|:||||:|.|:.||      |.:|:..|.    |:..|.|..
  Fly   272 VELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV------SLSPSSKKT----RLSRTGSRE-- 324

Human   309 RSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTT----ALQEALKEKQQHIEQLLA 369
               |.:|:.:|:|:|::.:|| .|.......||...:.|..|.    ::|:.|:|||||:|:|:.
  Fly   325 ---SLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMV 385

Human   370 ERDLERAEVAKATSHVGEIEQELALARD-------------------------GHDQHVL----- 404
            ||||:|.:.......:.:...|:.:..|                         ...||:.
  Fly   386 ERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTL 450

Human   405 --------------------------------------ELEAKMDQLR-TMVEAADREK------ 424
                                                  .|..|..|.: ..|...|::|
  Fly   451 SSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKA 515

Human   425 --VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRL 487
              |||.:.|:.|::|.|:||..::|......:|...:...|.:|.:||..:...|.....|:..|
  Fly   516 RIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSIL 580

Human   488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 552
            ..:.|:.|.    :|.:||:.||||:.:                      .|||:::  ...|:|
  Fly   581 PPDLPSDDG----ALQEEIAKLQEKMTI----------------------QQKEVES--RIAEQL 617

Human   553 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 617
             :|.:.|:..:::.|::    ||    .|::.:.|..:|:|:..:|               :..|
  Fly   618 -EEEQRLRENVKYLNEQ----IA----TLQSELVSKDEALEKFSLS---------------ECGI 658

Human   618 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 682
            |.:|    .|:|.|  ::::|:.|...:.|..|       |..|.|:|.:|.   .:|.|:|...
  Fly   659 ENLR----RELELL--KEENEKQAQEAQAEFTR-------KLAEKSVEVLRL---SSELQNLKAT 707

Human   683 EDTL-----NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL---KATEEKLLDLDALRKASSE 739
            .|:|     ||..|.||...|:.:...:..|..:.:|..|:||   ||....|.|:..|:|..:|
  Fly   708 SDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTE 772

Human   740 GKSEM-----KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN-LSEVSQ 798
            .||.:     |:|.|..|.|.|.:...|     :..|..|..::|..:|..:..:.|| ::::..
  Fly   773 EKSTLLEKTEKELVQSKEQAAKTLNDKE-----QLEKQISDLKQLAEQEKLVREMTENAINQIQL 832

Human   799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863
            .||::|::|.:.:.:..:..::....:..:||.  |....::.|.::.|.     |:|..::.:.
  Fly   833 EKESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESG-----ESLKKLQQQL 890

Human   864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 928
            .:|....|:|..|.|:|:.:...|:|.                 ||:::::||.|..::
  Fly   891 EQKTLGHEKLQAALEELKKEKETIIKE-----------------KEQELQQLQSKSAES------ 932

Human   929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 993
             :.:::.:.|:.||.||:||...||..|.:.:           .|::..:||::.|...||.|:.
  Fly   933 -ESALKVVQVQLEQLQQQAAASGEEGSKTVAK-----------LHDEISQLKSQAEETQSELKST 985

Human   994 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKSLTYLLTSAKKEIELMSEELR 1058
            ... |:...|.|......|:...:::..||:::.:|:.:..:.::   .|:|...::|..:::|.
  Fly   986 QSN-LEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQA---ALSSCHTDVESKTKQLE 1046

Human  1059 GLKSEKQLLSQEGNDLKLENGSLLSKLVELEAKI-ALLQGDQQKLWSVNETLNLEKEKFLEEKQD 1122
            ...:..:.:::|..:.:.|...|..|:.|:...: |.||.::    |.:..|:.:..||.:|...
  Fly  1047 AANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAER----SSSSALHTKLSKFSDEIAT 1107

Human  1123 AEKYYEQEHLNKEALAVEREKLLKEINVVQEELLKINVENDSLQASKVSMQALIEELQLSKDTLI 1187
            ..|     .|..:|.|..:|.|.||     :||                 |.|.::||.|:|:..
  Fly  1108 GHK-----ELTSKADAWSQEMLQKE-----KEL-----------------QELRQQLQDSQDSQT 1145

Human  1188 -AKTEKDQEEKDHLEDQIKKLITENFILAKDKDDIIQKLQRSYEELVKDQKALVQETEDLTAEKK 1251
             .|.|.:::||                              |:||.:|:.:      |::|..|.
  Fly  1146 KLKAEGERKEK------------------------------SFEESIKNLQ------EEVTKAKT 1174

Human  1252 SALEKLSNLDNTCIALKVERDNVLQNNRNLQLETDMLLQD-QEKLNASLQAALQVKQLLRSEASG 1315
            ..||                         |...|...::| ||:|..: .|.||.|:.:.||.:.
  Fly  1175 ENLE-------------------------LSTGTQTTIKDLQERLEIT-NAELQHKEKMASEDAQ 1213

Human  1316 LRAQLDDASKALRKAELETVQLEAANTSLTKLLEEIKARRAVTDSECIQLLHEKETLAASERRLL 1380
            ..|.|....:|::.|   ...:.|.|..|:.:||.::|.::.|:       |..|         |
  Fly  1214 KIADLKTLVEAIQVA---NANISATNAELSTVLEVLQAEKSETN-------HIFE---------L 1259

Human  1381 AEKEELLSENRIITEKLHKCLEEAAHTEMSLNEK-ITYLTSEKEMASQKMTELKKQQDS-LLKEK 1443
            .|.|..::..|:| ||:....||...|.:.|:|: ..:...|:::...:.:|.|.||:| ..|||
  Fly  1260 FEMEADMNSERLI-EKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK 1323

Human  1444 SSLETQNGALLAERENSIKAIGDLKRQCDQESANRSLVVQENMKLLGNIDALKKELQERKKENQE 1508
                      |.|.:.|::.:.|..:|.::                     |.:.|:|:.:|:..
  Fly  1324 ----------LTEIQQSLQELQDSVKQKEE---------------------LVQNLEEKVRESSS 1357

Human  1509 LVASKCDLSLMLKEAQNTKKN-----LEKEHTHILQAKESLDAQLNTCCSEKNILLRDGLNLQEE 1568
            ::           ||||||.|     ||.:.:.:   ||:.|..|.:...||        .||||
  Fly  1358 II-----------EAQNTKLNESNVQLENKTSCL---KETQDQLLESQKKEK--------QLQEE 1400

Human  1569 CHKLSKEIQEMQQSLILEQEARAKESESSLYENNQLHGRMVLLEQEVEELRVCIEELQSEKFVLL 1633
            ..|||.|:|::|::                  |..:...:|.:|
  Fly  1401 AAKLSGELQQVQEA------------------NGDIKDSLVKVE--------------------- 1426

Human  1634 QEKSKSEQELAEIIEEKELLTAEAAQLAAHIKTLKSDFAALSKSKAELQELHSCLTKILDDLQRN 1698
                    ||.:::|||  |.|..:||.|...|.|           |||||
  Fly  1427 --------ELVKVLEEK--LQAATSQLDAQQATNK-----------ELQEL-------------- 1456

Human  1699 HEVTLAEKAQVMQDNQNLLAEKSEMMLEKDELLKEKETLAESYFILQKEISQLAKTNSHISANLL 1763
                                                                           |:
  Fly  1457 ---------------------------------------------------------------LV 1458

Human  1764 ESQNENRTLRKDKNKLTLKIRELETLQSFTAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1828
            :||.....|:.:...:|.|:::||                                    |.|.:
  Fly  1459 KSQENEGNLQGESLAVTEKLQQLE------------------------------------QANGE 1487

Human  1829 LQNELDTLKENNLKNVE-ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1892
            |:..| ..|||.||.:: :|::|..:|..:.:...|.:.::|       |..|:...||||..||
  Fly  1488 LKEAL-CQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLE-------QAQQKERTLQEETSKL 1544

Human  1893 AEELGRSRDEVTSHQKLEE-ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1956
            ||:|.:.:      |..|| ::|:...|||..|..|      .|.:.|..||.|.......:.|.
  Fly  1545 AEQLSQLK------QANEELQKSLQQKQLLLEKGNE------FDTQLAEYQKVIDEMDDAASVKS 1597

Human  1957 AELEKLRNEV----TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 2017
            |.||:|:|.|    |.||..|.:.|:.:...:.|......|||:.....|.||......||.||.
  Fly  1598 ALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGK 1662

Human  2018 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 2082
            .|.....|.....::|:||||:|.|:|:||..||.||:.:....:     |.....:.|...:.|
  Fly  1663 GDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPM-----DFTKPHAFDALTKRK 1722

Human  2083 KKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHST--HHGSRGEE-------RPYCEICEMFGHW 2138
            ..|||||||||.||.|||||||.|.  |||..:||  ...:..|:       |.||:.||:|||.
  Fly  1723 PAPRLFCDICDEFDQHDTEDCPIQG--SEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHD 1785

Human  2139 ATNCNDDETF 2148
            .:.|.||||:
  Fly  1786 TSECADDETY 1795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP1	NP_001376220.1	CAP_GLY	60..124	CDD:396049	40/63 (63%)
		CAP_GLY	214..278	CDD:396049	40/66 (61%)
		SbcC	<335..835	CDD:223496	129/594 (22%)
		Smc	612..1442	CDD:224117	190/848 (22%)
		Smc	1176..1977	CDD:224117	175/815 (21%)
		CLIP1_ZNF	2126..2142	CDD:406934	8/15 (53%)
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	17/65 (26%)
		CAP_GLY	125..189	CDD:396049	40/63 (63%)
		CAP_GLY	239..306	CDD:396049	40/66 (61%)
		SMC_prok_B	<546..912	CDD:274008	102/445 (23%)
		Smc	734..1591	CDD:224117	268/1266 (21%)
		SHE3	1502..1702	CDD:293683	69/218 (32%)
		CLIP1_ZNF	1773..1789	CDD:406934	8/15 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141910
Domainoid	1	1.000	210	1.000	Domainoid score	I2817
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110101at2759
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm40362
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	1	1.000	-	-		X2251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.730