DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RREB1 and peb

DIOPT Version :9

Sequence 1:NP_001003699.1 Gene:RREB1 / 6239 HGNCID:10449 Length:1742 Species:Homo sapiens
Sequence 2:NP_001014722.1 Gene:peb / 31391 FlyBaseID:FBgn0003053 Length:1894 Species:Drosophila melanogaster


Alignment Length:2107 Identity:479/2107 - (22%)
Similarity:732/2107 - (34%) Gaps:752/2107 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     2 TSSSPAGLEGSDLSSINTM------MSAV-------MSVGKVTENGGSPQGIKSPSKP------P 47
            :::..:|..|:..|:.||.      .|||       .::...:.:.||..|....|.|      .
  Fly   172 STTGHSGYLGNSSSATNTTATSGIGASAVAPSPVGGAAINAASSSSGSSSGGSGGSSPQGQCLSS 236

Human    48 GPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADH-SCSICGKSLSSASS 111
            |.:.||..::..|     |.||:||.:..|.|:.|.|||.||...|..:: :|.||.|.||||||
  Fly   237 GESGIGAGDEHMK-----YLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASS 296

Human   112 LDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKD--PNSATATAPPSPLKRRRLSS---K 171
            ||||:|||:||||:.|..|..:|||||||||||:.|::.  ..|.:.:.....|::::.|.   :
  Fly   297 LDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQVAQSQSQSQQQQSLQQQQQSQQQRR 361

Human   172 RKLSHDAESEREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLR 236
            ::..|....::::||..:.|     ...|..:|:.......|..:.       :...:||     
  Fly   362 QQQQHQPSQQQQNPAQQQLM-----GNTLSARAESYESDASCSTDV-------SSGHSHS----- 409

Human   237 CDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCR-KFPRISQA 300
                    |:...|..:|...||            .||     ...||...:.|.. :.....|.
  Fly   410 --------RSSSSLNNNNNNSHK------------ANN-----NLKDLEELEVSTEDQDTENKQR 449

Human   301 WCETNLRRCI--SEQHRFV----CDTCDKAFPMLCS-------LALHKQTHVAADQGQEKPQATP 352
            ..:|.:...|  |||...:    .|..|.|  ||.|       ||....:..|:......|.|:|
  Fly   450 RLKTTINNNIIESEQQEDMDDEEADDADVA--MLTSTPDVATLLAGASASGAASRSPTPSPSASP 512

Human   353 ---LPGDALDQKGFLAL------LGLQHTKDVRPAPAEEPLPDDNQAI-----QLQTLKCQLPQD 403
               |...|.....|..|      |...|: |: ||...     |.:.|     |||:..|:||. 
  Fly   513 ALLLSCPACGASDFETLPALCVHLDAMHS-DI-PAKCR-----DCEVIFATHRQLQSHCCRLPN- 569

Human   404 PGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELA 468
                           :|.|.|..|.....|..|..          :|:.         |...:..
  Fly   570 ---------------ALAGGLPPLLGASSSPLHNE----------EPED---------EEHGDDE 600

Human   469 DIQQILKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQA 533
            |::|..::|:.:..                  |.|...||.|                      .
  Fly   601 DLEQKERLASQSED------------------FFHQLYLKHK----------------------T 625

Human   534 SPGCISPSLPPPPLKLLKGSVEAASNAHL--LQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQL 596
            :.||.:.|.||.|:|     .|.|....|  :||.......:::.|...:.....|...:     
  Fly   626 ANGCGAISHPPSPIK-----HEPADTKDLADIQSILNMTSSSSSFLRNFEQSVNTPNSSQ----- 680

Human   597 EQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVL----YPCRFCNQVFAFSGV 657
                       .|::.:.::|..:   .||        |...|::.    :||:.|..||.....
  Fly   681 -----------YSLDGRDQEEEAQ---DAF--------TSEFRRMKLRGEFPCKLCTAVFPNLRA 723

Human   658 LRAHVRSHLG----ISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHL 718
            |:.|.|.|||    ..|::||:|.|...|||||:||:|||:|:|||.|.:|:|.||.||||||||
  Fly   724 LKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHL 788

Human   719 RKKHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGED---------------------- 761
            |.:|.|.:|:::::.|.|   ..||  ||.| .|:..|| |||                      
  Fly   789 RNRHGKTSREEVKRAIVY---HPAE--DAGC-EDSKSRL-GEDLADTSFRSISPTPPPPPVNESK 846

Human   762 --LKH------------------------------------------------------------ 764
              |||                                                            
  Fly   847 SQLKHMLLGENHLAPVNQQPPLKIQVKSLDQLVDKKPSAPAPQQQQQQQQQEKSGSALDFSMDVL 911

Human   765 ----------------------------------------------------------------- 764
                                                                             
  Fly   912 DLSKKPTGGASLTPAVTRTPTPAAVAPVTPGGVGTPDLAAAIEQQQLLLAQQQLFGAGGEYMQQL 976

Human   765 YRALRIHMRTH---------------------------------CGRGLG-----GG-------- 783
            :|:|....:|.                                 .|.|:|     ||        
  Fly   977 FRSLMFQSQTSGFPFFPFMAPPPPQANPEKPPMVSPPNRINPMPVGVGVGVPVPPGGPVKMVIKN 1041

Human   784 -----------HKGRKPFECKECSAAFAAKRNCIHHILKQH--LHVPEQDIESYVLAADGLGPAE 835
                       ::..:||.|:.|||.|..:.|...|:.:||  .:...|....:|:...|.....
  Fly  1042 GVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASNVA 1106

Human   836 APAAEAS-----------------------GRGEDS----GCAALGD---CKPLTAFLEPQ---- 866
            |.||.|:                       |.|..|    |.|.:.:   |..|...|:..    
  Fly  1107 AAAAAAAAAAAATVMAGGPGSSGFGSNHHHGHGHGSHGSHGHAPISEQVKCAILAQQLKAHKNTD 1171

Human   867 ---------------NGFLHRG-P-TQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQ 914
                           |..||.| | |.|.|.|.........:.|:|.:||        .|:..:.
  Fly  1172 LLQQALAHGSSSVAGNPLLHFGYPLTNPSPMHNGSSQGNGQATAMDDDEP--------KLIIDED 1228

Human   915 ENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSL 979
            ||          .:|..:|..|:.   :|.: |:|   ..|..:||:|                 
  Fly  1229 EN----------EHDHEVEAEDVD---DFEE-DED---EEEMDEPEDE----------------- 1259

Human   980 PVTLGPSGILESPMAPAPAATPEPPAQPLQ--GPVQLAVPIYSSALVSSPPLVGSSALLSGTALL 1042
                 |..||:...|...|...:...:||:  |..:.|..:..:.|        ..|:.:|    
  Fly  1260 -----PELILDEQPAEKEAEEEQELPKPLEQLGTKEAAQKMAETIL--------EQAIKAG---- 1307

Human  1043 RPLRPKPPLLLPKPPVTEEL----PPLASIAQ--IISSVSSAPTLLKTKVADPGPASTGSNTTAS 1101
            :||.|        ||..|..    |.:|:..|  .|::.|:.|:.|||.:|.            :
  Fly  1308 KPLSP--------PPTKENASPANPTVATTMQEPAITAPSTNPSSLKTMIAQ------------A 1352

Human  1102 DSLGGSVPKAATTATPAATTSP-KESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRA 1165
            :.:|.|:.:.|        :|| |:.|:...|.:        :.....||:..|.....|....|
  Fly  1353 EYVGKSLKEVA--------SSPFKDESQDLVPVA--------KLVDNATSQNMGFNSYFRPSDVA 1401

Human  1166 NSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDK 1230
            |    .::.|.|...:....|:...|      ...||.|....:..|                  
  Fly  1402 N----HMEQSDEEGLVASGSASESNN------SGTEDVTSSSSSSEP------------------ 1438

Human  1231 LLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTGQKPFPCQKCDAFFSTKSNCERHQLR 1295
               .|:::|:....:::||:|.|:|||:|||:||:|||||||||.|..|...|:|||||:||.||
  Fly  1439 ---KKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLR 1500

Human  1296 KHGVTTCSLRRNGLIPQSKESDVGSHDSTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQV 1360
            |||              :.||.:..:..|:..|:......:.|.::|..:.|.|.:|...||.  
  Fly  1501 KHG--------------NVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAEREKELE-- 1549

Human  1361 AGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLM 1425
                      .|....:.||.....|....:|:....:.......|:.:|::.       |..::
  Fly  1550 ----------LERERELERERELERERQLEKEKERERQQLIQKLAAQMNAAAT-------AAAVV 1597

Human  1426 DFKLAEGDGEAG------AGGAASQEQKLACDTCGKSF-KFLGTLSRHRKAHGRQEPKDEKGDGA 1483
            ....|...|.:|      |...|..:....|..|..|| :.|..|...::||..:.        |
  Fly  1598 AAASAVNGGASGGPHGPIADALAGGDLPYKCHLCEGSFAERLQCLEHIKQAHAHEY--------A 1654

Human  1484 STAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDK 1548
            ....:|.......|..|.:.|::             :.:..:.|.|:.|           .:..|
  Fly  1655 LLLAKGAIETESLEANPHQQPSQ-------------QAVHSDDEAPNGG-----------GNRGK 1695

Human  1549 KPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRH 1613
            .|...:          ||.:|:.|.:||||.:||.||||:|:||||::|..|.|.||||||::||
  Fly  1696 YPDYSN----------RKVICAFCLRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRH 1750

Human  1614 QRIHQ-KARHAKHHGKD-SDKEERGEEDS-----------ENESTHSGNNAVSENEAELAPNASN 1665
            .:.|. :|.:....|.| ||.|:.....|           .|.|.|:.||..:.|.    .|.:|
  Fly  1751 MKKHSGRAHNGDTPGSDCSDDEQVSSPPSTPHPTQPTSANNNNSCHNNNNNANNNN----NNNNN 1811

Human  1666 HMAVTRSRKEGL--------AS---ATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQD---- 1715
            :.....|.|.||        ||   |::...|:|           ..|:..|......|.|    
  Fly  1812 NNNNNSSSKLGLKLHDLLDKASEWRASRLGEHKE-----------NMGEATPSGATVAGSDLIGN 1865

Human  1716 LLEPRSKRPAHPILATADGASQLVGME 1742
            ||....:...:.:|::||.|::|:|::
  Fly  1866 LLGISDQGILNKLLSSADEAAKLLGVD 1892

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RREB1NP_001003699.1 COG5048 <64..246 CDD:227381 61/187 (33%)
C2H2 Zn finger 68..88 CDD:275368 10/19 (53%)
C2H2 Zn finger 99..119 CDD:275368 15/19 (79%)
zf-H2C2_2 111..136 CDD:290200 15/24 (63%)
C2H2 Zn finger 127..147 CDD:275368 13/19 (68%)
C2H2 Zn finger 211..230 CDD:275368 1/18 (6%)
C2H2 Zn finger 237..253 CDD:275368 2/15 (13%)
C2H2 Zn finger 645..665 CDD:275368 7/19 (37%)
C2H2 Zn finger 673..693 CDD:275368 12/19 (63%)
zf-H2C2_2 685..709 CDD:290200 14/23 (61%)
C2H2 Zn finger 701..719 CDD:275368 12/17 (71%)
C2H2 Zn finger 755..775 CDD:275368 10/168 (6%)
C2H2 Zn finger 792..814 CDD:275368 9/23 (39%)
C2H2 Zn finger 1248..1268 CDD:275368 13/19 (68%)
zf-H2C2_2 1260..1285 CDD:290200 16/24 (67%)
C2H2 Zn finger 1276..1297 CDD:275368 12/20 (60%)
TMEM119 <1467..1531 CDD:292352 9/63 (14%)
C2H2 Zn finger 1569..1589 CDD:275368 12/19 (63%)
zf-H2C2_2 1581..1605 CDD:290200 14/23 (61%)
zf-C2H2 1595..1617 CDD:278523 11/21 (52%)
C2H2 Zn finger 1597..1617 CDD:275368 11/19 (58%)
pebNP_001014722.1 C2H2 Zn finger 252..272 CDD:275368 10/19 (53%)
C2H2 Zn finger 284..304 CDD:275368 15/19 (79%)
zf-H2C2_2 296..321 CDD:290200 15/24 (63%)
C2H2 Zn finger 312..332 CDD:275368 13/19 (68%)
C2H2 Zn finger 711..731 CDD:275368 7/19 (37%)
C2H2 Zn finger 743..763 CDD:275368 12/19 (63%)
zf-H2C2_2 755..780 CDD:290200 15/24 (63%)
C2H2 Zn finger 771..789 CDD:275368 12/17 (71%)
C2H2 Zn finger 1061..1079 CDD:275368 7/17 (41%)
PopZ 1299..>1430 CDD:226348 39/188 (21%)
C2H2 Zn finger 1453..1473 CDD:275370 13/19 (68%)
zf-H2C2_2 1465..1490 CDD:290200 16/24 (67%)
C2H2 Zn finger 1481..1502 CDD:275370 12/20 (60%)
C2H2 Zn finger 1706..1726 CDD:275368 12/19 (63%)
zf-H2C2_2 1718..1742 CDD:290200 14/23 (61%)
C2H2 Zn finger 1734..1754 CDD:275368 11/19 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159128
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BETZ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 387 1.000 Inparanoid score I2030
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D24048at33208
OrthoFinder 1 1.000 - - FOG0007124
OrthoInspector 1 1.000 - - oto89726
orthoMCL 1 0.900 - - OOG6_108574
Panther 1 1.100 - - LDO PTHR46451
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5213
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.850

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