DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BDKRB1 and PK2-R2

DIOPT Version :9

Sequence 1:	NP_000701.2	Gene:	BDKRB1 / 623	HGNCID:	1029	Length:	353	Species:	Homo sapiens
Sequence 2:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	78/336 - (23%)
Similarity:	139/336 - (41%)	Gaps:	48/336 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    22 NATACDNAPEAWDLLHRVLPTFIIS-----------ICFFGLLGNLFVLLVFLLPRRQLNVAEIY 75
            |.|:.....|..:||..|.|...:|           |...|:||||...:|.............|
  Fly    40 NLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFY 104

Human    76 LANLAASDLVFVL-GLPFWAENIWNQFNWPFGALLCRVINGVIK---ANLFISIFLVVAISQDRY 136
            |.|||.||::.:. |:|....|:|:..|:||...:| ::..|:.   ||  .::..:.|.:.:||
  Fly   105 LFNLAISDMILLCSGMPQDLYNLWHPDNYPFSDSIC-ILESVLSETAAN--ATVLTITAFTVERY 166

Human   137 RVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSI--QAVPDLNITACILLLPHEAWH 199
            ..:.||.......:..:|......||:...||::|..:..|:  |.:.    |:|.:.....|..
  Fly   167 IAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVVMQGMG----TSCTMKNDFFAHV 227

Human   200 FARIVELNILGFLL---PLAAIVFFNYHILASLRTRE----EVSRTRC-----GGRKDSKTTALI 252
            ||      :.|||.   |:.||...  ::|..::.:.    :....||     |....::...::
  Fly   228 FA------VSGFLFFGGPMTAICVL--YVLIGVKLKRSRLLQALPRRCYDVNRGISAQTRVIRML 284

Human   253 LTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGR 317
            :.:.|||.:||||:|....:........:...::.|...:....:....|.::.:||::|..:..
  Fly   285 VAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSH 349

Human   318 LFRTKVWELYK 328
            .||    |.:|
  Fly   350 KFR----EAFK 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BDKRB1	NP_000701.2	7tmA_BK-1	38..323	CDD:320502	71/313 (23%)
		TM helix 1	40..64	CDD:320502	9/34 (26%)
		TM helix 2	73..94	CDD:320502	9/21 (43%)
		TM helix 3	111..133	CDD:320502	4/24 (17%)
		TM helix 4	156..172	CDD:320502	4/15 (27%)
		TM helix 5	200..223	CDD:320502	8/25 (32%)
		TM helix 6	249..271	CDD:320502	8/21 (38%)
		TM helix 7	291..316	CDD:320502	4/24 (17%)
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	62/275 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910