DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB2 and JIL-1

DIOPT Version :9

Sequence 1:NP_003943.2 Gene:RPS6KB2 / 6199 HGNCID:10437 Length:482 Species:Homo sapiens
Sequence 2:NP_001261697.1 Gene:JIL-1 / 39241 FlyBaseID:FBgn0020412 Length:1207 Species:Drosophila melanogaster


Alignment Length:389 Identity:165/389 - (42%)
Similarity:237/389 - (60%) Gaps:16/389 - (4%)


- Green bases have known domain annotations that are detailed below.


Human    24 SPADACPLAELRAAGLEPVGHYEEVE-LTETSVNV---GPERIGPHCFELLRVLGKGGYGKVFQV 84
            :|:.|.|.:......|:...|..::| :|:....|   ..|.:..:.|:::||||.|.||:||.|
  Fly   214 TPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLV 278

Human    85 RKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV-KHPFIVELAYAFQTGGKLYLIL 148
            ||:...:.||:||||||.|..:|:..|...||:.||.:||:: ::||:|.|.||||:..||||:|
  Fly   279 RKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVL 343

Human   149 ECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDF 213
            :..:||||||||.....|.|.....|:||:.|||..||..||||||:|.|||:|..:|||.|:||
  Fly   344 DFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDF 408

Human   214 GLCKESIHEGAV-THTFCGTIEYMAPEILVRS---GHNRAVDWWSLGALMYDMLTGSPPFTAENR 274
            ||.|....|... .|:||||:||||||| :|:   ||:.||||||:|.|.:::|||:.||...:.
  Fly   409 GLSKILTAENEYRAHSFCGTLEYMAPEI-IRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDG 472

Human   275 KKTMDKIIR----GKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDD 335
            :....:|.|    .:..:|...:.:|||.|.|.|::||.:|:||...||::::.||||..:||.:
  Fly   473 QVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQE 537

Human   336 LLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIK 399
            |...|...|::|.|.:|:||..|...||.|.|.|...|.  ..|..:.|.|:|||||..|:.::
  Fly   538 LRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDA--PPSRIRLFRGYTYVAPEHLEQMR 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB2NP_003943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 0/1 (0%)
S_TKc 67..328 CDD:214567 128/269 (48%)
STKc_p70S6K 70..392 CDD:270736 152/330 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..482
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12529391 471..477
JIL-1NP_001261697.1 S_TKc 261..530 CDD:214567 128/269 (48%)
STKc_MSK_N 266..533 CDD:270735 128/267 (48%)
S_TK_X 532..591 CDD:214529 22/60 (37%)
S_TKc 632..886 CDD:214567
PKc_like 632..885 CDD:304357
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140566
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1132245at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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