DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KB2 and rsks-1

DIOPT Version :9

Sequence 1:	NP_003943.2	Gene:	RPS6KB2 / 6199	HGNCID:	10437	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_499447.2	Gene:	rsks-1 / 176554	WormBaseID:	WBGene00012929	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	472	Identity:	254/472 - (53%)
Similarity:	325/472 - (68%)	Gaps:	33/472 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAVFDLDLETEEGSEGEGEPELSP--ADACP-----------LAELRAAGLEPVGHY------E 46
            ||.||:.:|   ||.|.:..|:...  .|.|.           :|:.:.:...|...|      |
Worm     1 MADVFEFEL---EGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMME 62

Human    47 EVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAK 111
            .::|..:::|....|:||..|:||:|||||||||||||||..|::.|:|:|||||:||.||||.|
Worm    63 SIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQK 127

Human   112 DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLA 176
            |||||:|||||||:||.|||.:|.||||||||||||||.|||||||.||||||:|:|:.|.|||:
Worm   128 DTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLS 192

Human   177 EITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEIL 241
            ||.::|.|||.|||||||||||||:|.:.||:||||||||||.|.....||||||||||||||||
Worm   193 EIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEIL 257

Human   242 VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKR 306
            :|.||.:|||||||||||:|||||.||||||||:||:|||::|:|.||.||:.:||||:||.|||
Worm   258 MRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLKR 322

Human   307 NPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSP 371
            :...|:|.|..||.:::.|.||:..:|:.:.|.:::.||:|.::::||.|.||.|||:.||||||
Worm   323 HVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSP 387

Human   372 DDTALSESANQAFLGFTYVAPSVLDSIKE----GFSFQPKLRSPRRLNS--SPRAPVSPLKFSPF 430
            .:|..|.:.:..|:||||||||||:.:.:    |.|......|..|..:  |||.|..|...|..
Worm   388 CETNFSLNGDNPFVGFTYVAPSVLEMMNKGGHGGISVAHLASSMSRAGAAKSPRKPGDPETASIL 452

Human   431 EG-----FRPSPSLPEP 442
            .|     |...|:...|
Worm   453 HGGHSNLFGHGPNSEAP 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		9/26 (35%)
		S_TKc	67..328	CDD:214567	186/260 (72%)
		STKc_p70S6K	70..392	CDD:270736	213/321 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..482		12/43 (28%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12529391	471..477
rsks-1	NP_499447.2	S_TKc	83..344	CDD:214567	186/260 (72%)
rsks-1	NP_499447.2	STKc_p70S6K	86..408	CDD:270736	213/321 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161447995
Domainoid	1	1.000	412	1.000	Domainoid score	I378
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I805
Isobase	1	0.950	-	0	Normalized mean entropy	S756
OMA	1	1.010	-	-		QHG51952
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		otm16034
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750