DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB1 and YPK3

DIOPT Version :10

Sequence 1:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens
Sequence 2:NP_009584.1 Gene:YPK3 / 852316 SGDID:S000000232 Length:525 Species:Saccharomyces cerevisiae


Alignment Length:421 Identity:159/421 - (37%)
Similarity:220/421 - (52%) Gaps:80/421 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    74 ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKA--MIVRNAKD 136
            |.|..::|.....:|     :||||:|.||||..|:.|   ||.|::|||.|:||  :|.:.|.|
Yeast   116 IGENELSRNLHDFKP-----VRVLGQGAYGKVLLVKDV---NTSKLYAMKQLRKAEILISQTATD 172

Human   137 T-----------------------AHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGG 178
            :                       ..|.|||:||.|::||.||.|.|:|....||||:|:|:.||
Yeast   173 SKREDEDKNDGNNNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGG 237

Human   179 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKES 243
            |||..|:..|...|.|..||.||||.||..||.||::||||||||.:||.:||:.||||||.|:|
Yeast   238 ELFYHLKEHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKS 302

Human   244 IHDGTV----------THTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENR 298
            .:|..|          .::..||.||.|||||:...:::..||:|||.|:||||.|.||:||.|.
Yeast   303 ANDSAVDEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNH 367

Human   299 KKTIDKILKCKL--NLPPYLTQEARDLLKKLLKRNAASR---------LGA------------GP 340
            |..|:||.:.|.  .:|.||::..:|:|..|||:..|.|         .||            |.
Yeast   368 KVIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGA 432

Human   341 GDAGEVQAHPFFRHINWEEL----LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS--- 398
            ........|..||.|:|:.|    |.:....|..|::...|....||::||..:..::..||   
Yeast   433 ARTSLFTEHFIFRKIDWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPI 497

Human   399 ---TLSESANQVFLGFTYVAPSVLESVKEKF 426
               ::|:|.: :|.||:|.|..   |..||:
Yeast   498 NINSVSKSPD-MFKGFSYKASG---SYLEKY 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
TOS motif 28..32
STKc_p70S6K 94..416 CDD:270736 151/389 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 6/24 (25%)
Autoinhibitory domain 424..525 2/3 (67%)
YPK3NP_009584.1 STKc_AGC 134..406 CDD:270693 123/274 (45%)
S_TK_X 445..516 CDD:214529 20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

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