DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB1 and Pkc53E

DIOPT Version :10

Sequence 1:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens
Sequence 2:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster


Alignment Length:363 Identity:144/363 - (39%)
Similarity:222/363 - (61%) Gaps:22/363 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    75 SETSVNRGPEK--IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 137
            |:|:.:...:|  ||...|..::|||||.:|||....:   ..:.:::|:|:|||.:|::: .|.
  Fly   332 SDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAER---KGSEELYAIKILKKDVIIQD-DDV 392

Human   138 AHTKAERNILE-EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 201
            ..|..|:.:|. ..|.||:|.|...|||..:|:.::||::||:|..|:::.|.|.|..|.||.||
  Fly   393 ECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAE 457

Human   202 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
            |:..|..||.|||:|||||.:|::|:..||||:.|||:|||:|.....|.|||||.:|:||||::
  Fly   458 IAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIIL 522

Human   267 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRN 331
            ...:.::||||:.|.|:|:||.|.|||.||:.::....|....::.|..|::||::..|..|.:.
  Fly   523 YQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQ 587

Human   332 AASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQ----TPV 392
            ...|||.|.....:|:.|||||.|:||::..|:|:|||||.::..:|||.||.:||.:    ||.
  Fly   588 PNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPT 652

Human   393 DSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEP 430
            |......|.:|.   |:||:|:.|        ::.|.|
  Fly   653 DKVFMMNLDQSE---FVGFSYMNP--------EYVFSP 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
TOS motif 28..32
STKc_p70S6K 94..416 CDD:270736 135/326 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 8/22 (36%)
Autoinhibitory domain 424..525 2/7 (29%)
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386
C2_PKC_alpha_gamma 177..307 CDD:175992
STKc_cPKC 353..672 CDD:270739 135/325 (42%)
Blue background indicates that the domain is not in the aligned region.

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