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Protein Alignment RPS6KB1 and aPKC

DIOPT Version :10

Sequence 1:	NP_003152.1	Gene:	RPS6KB1 / 6198	HGNCID:	10436	Length:	525	Species:	Homo sapiens
Sequence 2:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	163/415 - (39%)
Similarity:	237/415 - (57%)	Gaps:	39/415 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    33 DQPEDAGSEDELEEGGQLNESMDHGGVG----PYEL---GMEHCEKFEISETSVNRGPE-KIRP- 88
            ||||....|       :..||.|...|.    |||.   |.|.||..:.:.......|| .:.|
  Fly   549 DQPEPLVKE-------RAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPG 606

Human    89 -------ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 146
                   ..|||:||:|:|.|.||..|..   ..|.:|:||||:||| :|.:.:|....:.|:::
  Fly   607 TQRQYSLNDFELIRVIGRGSYAKVLMVEL---RRTRRIYAMKVIKKA-LVTDDEDIDWVQTEKHV 667

Human   147 LEEV-KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
            .|.. .|||:|.|...|||..:|:.::|::.||:|...::|:....|:.|.||.||||:||..||
  Fly   668 FETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLH 732

Human   211 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVD 275
            :|||||||||.:|::|:|:||:||||:|:|||.|..|..|.|||||..|:|||||....:..:||
  Fly   733 EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 797

Human   276 WWSLGALMYDMLTGAPPF----TGENRKKTIDK-----ILKCKLNLPPYLTQEARDLLKKLLKRN 331
            ||:||.|:|:||.|..||    ..||..:..:.     ||:..:.:|..|:..|..:||..|.:|
  Fly   798 WWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKN 862

Human   332 AASRLGAGPGDA-GEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSP 395
            .|.|||.....| .::.:||||::::||.|..::|.|||||.|.|:.|::.|..:||.:....:|
  Fly   863 PADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTP 927

Human   396 DDSTLSESANQ-VFLGFTYVAPSVL 419
            ||..:.::.:| .|.||.||.|.::
  Fly   928 DDDHVIDNIDQSEFEGFEYVNPLLM 952

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.