DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB1 and Akt

DIOPT Version :10

Sequence 1:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens
Sequence 2:NP_732113.3 Gene:Akt / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster


Alignment Length:398 Identity:165/398 - (41%)
Similarity:232/398 - (58%) Gaps:39/398 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    20 EAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVN-RGP 83
            |..||.   |:|:    ...:||||.                        |:|.:..|:.| .|.
  Fly   225 EQTDMT---DVDM----ATIAEDELS------------------------EQFSVQGTTCNSSGV 258

Human    84 EKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 148
            :|:..|.||.|:|||||.:|||...|:..   |.|::|:|:|||.:|::. .:.|||..|..:|:
  Fly   259 KKVTLENFEFLKVLGKGTFGKVILCREKA---TAKLYAIKILKKEVIIQK-DEVAHTLTESRVLK 319

Human   149 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
            ...|||::.|.|:|||..:|..:::|::|||||..|..|.||.||...||.|||..|||:||.:|
  Fly   320 STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQG 384

Human   214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWS 278
            |||||||.||::|:..||:|:.|||||||.|..|..|.|||||.||:|||:|..:.:.:|||||.
  Fly   385 IIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWG 449

Human   279 LGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDA 343
            .|.:||:|:.|..||...:.......||..::..|..:|.||::||..||.::...|||.|..|.
  Fly   450 TGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDV 514

Human   344 GEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDST--LSESANQ 406
            .|:||||||..|||.:|:.:|:.|||||.:.|:.|...||.:||.::...:|.|.|  |...|.:
  Fly   515 KEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEE 579

Human   407 -VFLGFTY 413
             :|..|:|
  Fly   580 PLFPQFSY 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 9/33 (27%)
TOS motif 28..32 1/3 (33%)
STKc_p70S6K 94..416 CDD:270736 147/323 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 6/18 (33%)
Autoinhibitory domain 424..525
AktNP_732113.3 PH_PKB 105..214 CDD:269947
STKc_PKB 270..590 CDD:270723 146/322 (45%)
Blue background indicates that the domain is not in the aligned region.

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