Protein Alignment RPS6KB1 and rps6kb1b

DIOPT Version :10

• Sequence 1: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Sequence 2: NP_998241.1
• Gene: rps6kb1b / 406349
• ZFINID: ZDB-GENE-040426-2038
• Length: 502
• Species: Danio rerio
• Alignment Length: 506
• Identity: 427/506 - (84%)
• Similarity: 458/506 - (90%)
• Gaps: 8/506 - (1%)

Human    24 MAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRP 88
            |||||||||||||:..|:||||| .|:||.||.  ...:|..|:.|||.||||.:||:|.|.|||
Zfish     1 MAGVFDIDLDQPEENVSDDELEE-AQINELMDQ--CSGFEFNMDDCEKIEISEDNVNQGTENIRP 62

Human    89 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 153
            |||||||||||||||||||||||:||.||||||||||||||||||||||||||||||||||||||
Zfish    63 ECFELLRVLGKGGYGKVFQVRKVSGAATGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 127

Human   154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD 218
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   128 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD 192

Human   219 LKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM 283
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   193 LKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM 257

Human   284 YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQA 348
            ||||||||||||||||||||||||||||||||||||||||||:||||:|:||||||||||.|||.
Zfish   258 YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQT 322

Human   349 HPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTY 413
            ||||||:||::||||||||||||.||..|||||||||||.|||||||||||||||||||||||||
Zfish   323 HPFFRHVNWDDLLARKVEPPFKPFLQFAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTY 387

Human   414 VAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGAS-ASTANPQTPVEYPME 477
            |||||||::||||||||||||||||:||||||:||:||| ||.|.||.: ..::..|:|.|..||
Zfish   388 VAPSVLENIKEKFSFEPKIRSPRRFLGSPRTPLSPIKFS-GDCWPRGPTLPGSSTLQSPTELAME 451

Human   478 TSGIEQMDVTMSGEASAPLPIRQP---NSGPYKKQAFPMISKRPEHLRMNL 525
            .|.::.|||..|.||:||||||||   |.|.:|:||:|:||||||||||||
Zfish   452 VSSVDHMDVQASAEATAPLPIRQPAGSNMGQFKQQAYPVISKRPEHLRMNL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		22/29 (76%)
		TOS motif	28..32		3/3 (100%)
		STKc_p70S6K	94..416	CDD:270736	306/321 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399		17/18 (94%)
		Autoinhibitory domain	424..525		67/104 (64%)
rps6kb1b	NP_998241.1	STKc_p70S6K	68..390	CDD:270736	306/321 (95%)