DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB1 and trc

DIOPT Version :10

Sequence 1:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens
Sequence 2:NP_001262071.1 Gene:trc / 40165 FlyBaseID:FBgn0003744 Length:463 Species:Drosophila melanogaster


Alignment Length:408 Identity:132/408 - (32%)
Similarity:215/408 - (52%) Gaps:78/408 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    63 ELGMEHCEKFEISETSVNRGPE-KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
            |..::|.:|    ||...|... ::..|.||.|:|:|:|.:|   :||.|...:||.::|||||:
  Fly    68 EKRLQHAQK----ETEYLRLKRLRLGVEDFEALKVIGRGAFG---EVRLVQKKDTGHVYAMKVLR 125

Human   127 KAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
            ||.::.. :..||.:|||::|.|..|.::|.:.|:||....||||:|:|.||::...|.::....
  Fly   126 KADMLEK-EQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLS 189

Human   192 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC---------------- 240
            |:...||::|.::|:..:|:.|.|:||:||:|::|:.:||:||:|||||                
  Fly   190 EEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLS 254

Human   241 --KESIHDGTVTHTFC------------------------GTIEYMAPEILMRSGHNRAVDWWSL 279
              |.|...||.....|                        ||.:|:|||:.:::|:..|.|||||
  Fly   255 QAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSL 319

Human   280 GALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLKKLLKRNAASRLGAGP 340
            |.:||:||.|.|||..:|.:.|..|::..:  |..||.  :::||::.:.... ..|..|||:..
  Fly   320 GVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFC-CEADRRLGSQR 383

Human   341 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESA- 404
            | ..::::.||||.::||.:..|....|.:  ::|.:|.|.||         :.||.|....|| 
  Fly   384 G-LEDLKSVPFFRGVDWEHIRERPAAIPVE--VRSIDDTSNFD---------EFPDVSLEIPSAP 436

Human   405 ---------NQVFLGFTY 413
                     :.||:.:||
  Fly   437 IPQGGEIAKDWVFINYTY 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
TOS motif 28..32
STKc_p70S6K 94..416 CDD:270736 123/376 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 5/18 (28%)
Autoinhibitory domain 424..525
trcNP_001262071.1 MobB_Trc-like 24..88 CDD:439274 6/23 (26%)
STKc_NDR_like 91..455 CDD:270750 126/381 (33%)
Blue background indicates that the domain is not in the aligned region.

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