Protein Alignment RPS6KB1 and JIL-1

DIOPT Version :10

• Sequence 1: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Sequence 2: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 454
• Identity: 172/454 - (37%)
• Similarity: 253/454 - (55%)
• Gaps: 52/454 - (11%)

Human    15 DFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG------------------- 60
            |.||.|.|    .:|.|:::.|..|.|.: |....|:::..:....
  Fly   153 DGRDPERE----YYDQDMEEDEPNGIEID-ESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSS 212

Human    61 ---PYELGMEHCEKFEISETSVNR---------------GPEKIRPECFELLRVLGKGGYGKVFQ 107
               .|.:...:....::...:..|               ..|.:....|:::||||.|.||:||.
  Fly   213 TTPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFL 277

Human   108 VRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV-KHPFIVDLIYAFQTGGKLYLI 171
            |||:|..:.||::|||||.|..:|:..|...|||.||.:||.: ::||:|.|.||||:..||||:
  Fly   278 VRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLV 342

Human   172 LEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTD 236
            |::.:|||||..|.....|.|.....|:||:.:||..|||.||||||:|.|||:|:.:||:.|:|
  Fly   343 LDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSD 407

Human   237 FGLCKESIHDGTV-THTFCGTIEYMAPEILMRS--GHNRAVDWWSLGALMYDMLTGAPPFT---G 295
            |||.|....:... .|:||||:|||||||:...  ||:.||||||:|.|.:::||||.||.   |
  Fly   408 FGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDG 472

Human   296 ENRKKTID-KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEE 359
            :.::..|. :|.|.:..:|...:..|||.:.|:|::|...|||....||.|::.||||..|||:|
  Fly   473 QVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQE 537

Human   360 LLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVK 423
            |..::.:.|:||.|.:|:||..|.::||.|.|.|...|:  ..|..::|.|:|||||..||.::
  Fly   538 LRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDA--PPSRIRLFRGYTYVAPEHLEQMR 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		12/38 (32%)
		TOS motif	28..32		1/3 (33%)
		STKc_p70S6K	94..416	CDD:270736	152/329 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399		7/18 (39%)
		Autoinhibitory domain	424..525		172/454 (38%)
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	126/266 (47%)
		S_TK_X	532..591	CDD:214529	24/60 (40%)
		S_TKc	632..886	CDD:214567