Protein Alignment RPS6KB1 and S6k

DIOPT Version :10

• Sequence 1: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Sequence 2: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 295/518 - (56%)
• Similarity: 359/518 - (69%)
• Gaps: 67/518 - (12%)

Human    20 EAEDMAGVFDIDLDQPE--DAGSEDELEEGGQLNESMDHGGVGPYELGMEHC----------EKF 72
            :..|.:.:||::|...|  |..:.|..::..:|::         .:|..|.|          |..
  Fly     3 DVSDPSELFDLELHDLELQDDKARDSDDDRIELDD---------VDLEPELCINLHQDTEGQETI 58

Human    73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 137
            ::.|.:||.|..|:.|:.|||.:|||||||||||||||..|.:..|.|||||||||.||.|.|||
  Fly    59 QLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDT 123

Human   138 AHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202
            |||:|||||||.|||||||:|:|||||.|||||||||||||||||.|||||||:|||.||||:||
  Fly   124 AHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEI 188

Human   203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 267
            .:||||||:.||||||||||||:|:.||||||||||||||.|.:|.|||||||||||||||||.|
  Fly   189 ILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTR 253

Human   268 SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
            |||.:|||||||||||:|||||.||||.|||||||:.|||.|||||.|||.|||||:::|:||..
  Fly   254 SGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQE 318

Human   333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDD 397
            ..|||:||.||..||.||||:|:||:::|||::|||.||||:||:||||||::||||.|||||||
  Fly   319 PQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDD 383

Human   398 STLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPR-TPVSPVKFSPGDFWGRGA 461
            :|||||||.:|.||||||||:||.:..  :.....|||||   :|| .|.|..:
  Fly   384 TTLSESANLIFQGFTYVAPSILEDMHR--ANRMPARSPRR---TPRQLPDSSFR----------- 432

Human   462 SASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPI--RQPNSGPYKKQAFPMISKRPEHLR 522
                      :::|....|           |:|||.:  ....||.:.: |.|     |.|::
  Fly   433 ----------LQFPSANVG-----------ANAPLAMHGHSQRSGMFAR-ATP-----PHHMQ 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		8/35 (23%)
		TOS motif	28..32		2/3 (67%)
		STKc_p70S6K	94..416	CDD:270736	248/321 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399		15/18 (83%)
		Autoinhibitory domain	424..525		21/102 (21%)
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	248/320 (78%)