DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KB1 and CG4839

DIOPT Version :10

Sequence 1:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens
Sequence 2:NP_609349.1 Gene:CG4839 / 34348 FlyBaseID:FBgn0032187 Length:1003 Species:Drosophila melanogaster


Alignment Length:349 Identity:110/349 - (31%)
Similarity:179/349 - (51%) Gaps:27/349 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    39 GSEDELEE--GGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101
            |:..:|.|  ..|.|::.........|...|: .:..|||              .:.:..||.|.
  Fly   655 GTIKQLREKPSSQRNDTSGRSSTKSLEFDNEY-SQVAISE--------------LKKIATLGCGA 704

Human   102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTG 165
            :|:|..|     |...:..|:|::||..:|:. ....|...|:|::.:.:. ||||.|...::..
  Fly   705 FGRVDLV-----AYNQQALALKIIKKIEVVKQ-DQIEHVYNEKNVMIKCRQSPFIVQLYRTYRND 763

Human   166 GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG 230
            ..:|.::|...||:::..:.:...|.|.||.|....:..|..:||....|||||||||:||...|
  Fly   764 KYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDG 828

Human   231 HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG 295
            :.||.|||..| .:.....|:||.||.||:||||::..||:||||:|:||.|:|::|.|..||.|
  Fly   829 YCKLVDFGFAK-FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRG 892

Human   296 ENRKKTIDKILK--CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWE 358
            .|:.|...:||.  ..:::|..:.:.|:.|::.|.|:..|.|||.......:::.|.:|..::|:
  Fly   893 VNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQ 957

Human   359 ELLARKVEPPFKPLLQSEEDVSQF 382
            .|..:::..|.|..|:|..|:..|
  Fly   958 RLKLKQLPSPIKRPLKSWTDLQYF 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 5/16 (31%)
TOS motif 28..32
STKc_p70S6K 94..416 CDD:270736 100/292 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 1/3 (33%)
Autoinhibitory domain 424..525
CG4839NP_609349.1 CAP_ED 431..539 CDD:237999
CAP_ED 550..663 CDD:237999 2/7 (29%)
STKc_cGK 700..957 CDD:270724 92/263 (35%)
Blue background indicates that the domain is not in the aligned region.

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