Protein Alignment RPS6KB1 and rsks-1

DIOPT Version :10

• Sequence 1: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Sequence 2: NP_499447.2
• Gene: rsks-1 / 176554
• WormBaseID: WBGene00012929
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 512
• Identity: 277/512 - (54%)
• Similarity: 345/512 - (67%)
• Gaps: 40/512 - (7%)

Human    24 MAGVFDIDLDQPEDAGSED----------ELEEGGQLNESMDHGGVG---PYELGMEH--CEKFE 73
            ||.||:.:|:..|...|..          |:.|...:..::..|.:.   |....||.  .|..:
 Worm     1 MADVFEFELEGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMMESIQ 65

Human    74 ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 138
            :..:::|....::.||.|:||:|||||||||||||||.||::.|:|||||||:||.||||.||||
 Worm    66 LCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQKDTA 130

Human   139 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 203
            ||||||||||.||.|||.||:|||||||||||||||||||||||.|||||:|||:.|.|||:||.
 Worm   131 HTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIV 195

Human   204 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 268
            ::|.||||:||||||||||||:|:..|||||||||||||.|.....||||||||||||||||||.
 Worm   196 VSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRC 260

Human   269 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
            ||.:|||||||||||:|||||.||||.|||:||||||||.:|.||.||:.|||||:||||||:..
 Worm   261 GHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLKRHVD 325

Human   334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS 398
            :|||||..||.|:::|.||:..:|..:.||::|.||||.::::||.|.||::||:.||||||.::
 Worm   326 TRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSPCET 390

Human   399 TLSESANQVFLGFTYVAPSVLESVKE-------------KFSFEPKIRSPRRFIGSPRTPVSPVK 450
            ..|.:.:..|:|||||||||||.:.:             ..|.....:|||: .|.|.| .|.:.
 Worm   391 NFSLNGDNPFVGFTYVAPSVLEMMNKGGHGGISVAHLASSMSRAGAAKSPRK-PGDPET-ASILH 453

Human   451 FSPGDFWGRGASASTANPQTPVEYPMETSGI-EQMDVTMSGEASAPLPIRQPNSGPY 506
            ....:.:|.|     .|.:.|..:..   || .||..|.:|.|....|. |..||.|
 Worm   454 GGHSNLFGHG-----PNSEAPQAFGY---GIGSQMTTTTAGGAGIQQPY-QSFSGGY 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		9/39 (23%)
		TOS motif	28..32		1/3 (33%)
		STKc_p70S6K	94..416	CDD:270736	228/321 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399		11/18 (61%)
		Autoinhibitory domain	424..525		24/97 (25%)
rsks-1	NP_499447.2	STKc_p70S6K	86..408	CDD:270736	228/321 (71%)