DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA3 and YPK3

DIOPT Version :9

Sequence 1:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens
Sequence 2:	NP_009584.1	Gene:	YPK3 / 852316	SGDID:	S000000232	Length:	525	Species:	Saccharomyces cerevisiae

Alignment Length:	427	Identity:	145/427 - (33%)
Similarity:	213/427 - (49%)	Gaps:	68/427 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    34 GEEEINPQTEEVSI-KEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLY 97
            |.:.:...|..:|| .:..|:.::.|.....:...|:.::|||||::|||.|||.::.|   :||
Yeast    93 GSDAMRTNTNRLSITPQDIISSNIGENELSRNLHDFKPVRVLGQGAYGKVLLVKDVNTS---KLY 154

Human    98 AMKVLKKATLKVRDRV---------------------------RTKMERDILVEVNHPFIVKLHY 135
            |||.|:||.:.:....                           ||..||.||.|:.||.||||.|
Yeast   155 AMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFY 219

Human   136 AFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENIL 200
            :|....||||:|.::.||:||..|.:.....|..|.||.||::.||..||:.|::||||||||.|
Yeast   220 SFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCL 284

Human   201 LDEEGHIKLTDFGLSKES-----IDHE-----KKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFG 255
            |::.||:.||||||||:|     :|.|     ...||..||.||.|||::..:.::|:.||:|.|
Yeast   285 LNQRGHLVLTDFGLSKKSANDSAVDEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLG 349

Human   256 VLMFEMLTGTLPFQGKDRKETMTMILKAKLG--MPQFLSPEAQSLLRMLFKRNPANRL-VNPFLI 317
            .|:::||.|..|:.|.:.|..:..|.:.|.|  :|.:||...:.:|..|.|:..|.|. |:.:..
Yeast   350 CLLYDMLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWA 414

Human   318 GAG----PDGVEEIK----------RHSFFSTIDWNKLYRREIHP----PFKPATGRPEDTFYFD 364
            ..|    |...::.|          .|..|..|||..|...::..    |..|.....|....||
Yeast   415 KTGANNKPTKSKKKKSGAARTSLFTEHFIFRKIDWKLLESGQLQKTTLGPIVPVITDLELAENFD 479

Human   365 PEFTA----KTPKDSP--GIPPSANAHQLFRGFSFVA 395
            .|||:    :|..||.  .|...:.:..:|:|||:.|
Yeast   480 TEFTSMSYEETYTDSKPININSVSKSPDMFKGFSYKA 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	117/318 (37%)
		STKc_RSK_N	72..394	CDD:270734	137/385 (36%)
		STKc_RSK2_C	408..737	CDD:271078
		Pkinase	428..685	CDD:278497
YPK3	NP_009584.1	STKc_AGC	134..406	CDD:270693	109/274 (40%)
YPK3	NP_009584.1	S_TK_X	445..516	CDD:214529	20/70 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159045388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870