Protein Alignment RPS6KA3 and Pka-C2

DIOPT Version :10

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Alignment Length: 331
• Identity: 116/331 - (35%)
• Similarity: 182/331 - (54%)
• Gaps: 38/331 - (11%)

Human    73 VLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM------ERDILVEVNHPFIV 131
            |||.||||.|.||::.||   :..||.|::.|     .|.||.|.      |:.:|.....||::
  Fly    50 VLGNGSFGTVMLVREKSG---KNYYAAKMMSK-----EDLVRLKQVAHVHNEKHVLNAARFPFLI 106

Human   132 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKP 196
            .|..:.:....|||||..:.||:||:...:...|.|:..:||.|::||||:::|.:.::||||||
  Fly   107 YLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKP 171

Human   197 ENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261
            ||||||:.|:||:||||.:|..   :.:..:.|||.||:|||:|..|.:.:|.|||:||:|::|.
  Fly   172 ENILLDQRGYIKITDFGFTKRV---DGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEF 233

Human   262 LTGTLPFQGKDRKETMTMILKAKL-----GMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGP 321
            :.|..||...:|.   .:::.:|:     .||.:.:.:.:||:..|.:.:.:.||      |...
  Fly   234 VAGRSPFAIHNRD---VILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRL------GNSN 289

Human   322 DGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAH- 385
            ||..::|.|.:|..:||..:..:|:..|::|.....||...|: .|..|....|     ..|.|
  Fly   290 DGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFE-NFEFKDRYKS-----RINRHP 348

Human   386 QLFRGF 391
            :||..|
  Fly   349 ELFANF 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	116/331 (35%)
		STKc_RSK2_C	408..737	CDD:271078
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	108/304 (36%)