DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RPS6KA3 and Akt

DIOPT Version :10

Sequence 1:XP_011543857.1 Gene:RPS6KA3 / 6197 HGNCID:10432 Length:746 Species:Homo sapiens
Sequence 2:NP_732113.3 Gene:Akt / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster


Alignment Length:404 Identity:162/404 - (40%)
Similarity:234/404 - (57%) Gaps:34/404 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    17 SPSDSAENGQQIMDEPM---GEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS 78
            :||:..:    :.|..|   .|:|:   :|:.|::.....   ..|.:|.....||.|||||:|:
  Fly   222 TPSEQTD----MTDVDMATIAEDEL---SEQFSVQGTTCN---SSGVKKVTLENFEFLKVLGKGT 276

Human    79 FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 142
            ||||.|.::   ....:|||:|:|||..:..:|.| .|..|..:|...||||::.|.|:|||..:
  Fly   277 FGKVILCRE---KATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDR 338

Human   143 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 207
            |..::.::.||:||..||.|.:|||:..:||.||:..||.:|||.||||||||.||:|||::|||
  Fly   339 LCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI 403

Human   208 KLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKD 272
            |:.||||.||.|.:.:...:||||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|
  Fly   404 KVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRD 468

Human   273 RKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTID 337
            .....|:||..::..|:.::.||::||..|..::|..||      |.|.|.|:||:.|.||::|:
  Fly   469 HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRL------GGGKDDVKEIQAHPFFASIN 527

Human   338 WNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----TPKDSPGIPPSANAHQLFRGFSFVAITS 398
            |..|..::|.|||||......||.|||.|||.:    ||.|..|...|.....||..||:     
  Fly   528 WTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY----- 587

Human   399 DDESQAMQTVGVHS 412
              :.....|:|..|
  Fly   588 --QGDMASTLGTSS 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KA3XP_011543857.1 STKc_RSK_N 72..394 CDD:270734 146/326 (45%)
STKc_RSK2_C 408..737 CDD:271078 2/5 (40%)
AktNP_732113.3 PH_PKB 105..214 CDD:269947
STKc_PKB 270..590 CDD:270723 146/335 (44%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.