Protein Alignment RPS6KA3 and CG32944

DIOPT Version :10

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: NP_788574.3
• Gene: CG32944 / 40560
• FlyBaseID: FBgn0052944
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 123/442 - (27%)
• Similarity: 196/442 - (44%)
• Gaps: 82/442 - (18%)

Human    54 HHVKEGHEKADPSQ---------FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKV 109
            |.:..||......|         |::|:.:|:||||||.:|:|   .|...|||||.:.::..::
  Fly   128 HSLAMGHMLCVKCQSLIPINFDHFQILRAIGKGSFGKVCIVQK---RDTGILYAMKYVSRSACEM 189

Human   110 RDRVRTKM-ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 173
            |..:...: |.::|..:.|||:|.|.::||.|..|:::.|.|.||||...|...|.|:|:.|...
  Fly   190 RGALGGVIKEVELLSSLEHPFLVNLWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALL 254

Human   174 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 238
            :.||..||::|.:..:::||:||:|||||:.||..||||.::.. :.....|.|..||..|||||
  Fly   255 VCELGSALEYLQANRVVHRDIKPDNILLDDAGHAHLTDFNIATR-LQKNALACSMSGTKPYMAPE 318

Human   239 VV-----NRRGHTQSADWWSFGVLMFEMLTGTLPF--QGKDRKETMTMILKAKLGMPQFLSPEAQ 296
            |.     ...|::...||||.||:.:||.....||  ........:..||...:..|::.|....
  Fly   319 VFLCALDEVAGYSYPVDWWSLGVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPRYWSSNFV 383

Human   297 SLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTF 361
            .||:.|....|..|:...          :|:.:......||:.::..::|.|.:||    |||..
  Fly   384 DLLQRLLSTYPGARISTR----------QELHQTPMLRNIDFQRVLEKKIKPIYKP----PEDHL 434

Human   362 YFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQL-HRNSIQFT 425
            ..||                               ..:.|...:::..:|...::| .:.|.|..
  Fly   435 NCDP-------------------------------CLELEEMIVESRPLHKKKKRLAKQRSAQRD 468

Human   426 DGYE---VKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILL 474
            ...|   |||.|....|...||            |.:::.:.|...|:|:.:
  Fly   469 SDPETALVKEFIVYNRYKELKR------------KAMEQKENDWQRELELAM 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	100/329 (30%)
		STKc_RSK2_C	408..737	CDD:271078	16/71 (23%)
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	91/273 (33%)