Protein Alignment RPS6KA3 and Pka-C3

DIOPT Version :10

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 364
• Identity: 127/364 - (34%)
• Similarity: 210/364 - (57%)
• Gaps: 23/364 - (6%)

Human    14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS 78
            |.::..||:|:.::.......:||.:.::||.|..:.|      :|..|.....::::|.:|.|:
  Fly   226 ADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTA------KGVRKYHLDDYQIIKTVGTGT 284

Human    79 FGKVFLVK-KISGSDARQLYAMKVLKKA-TLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEG 141
            ||:|.|.: :||    .:..|||:|... .::::.....|.||:||.|:.|||::.|.::.:.:.
  Fly   285 FGRVCLCRDRIS----EKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDS 345

Human   142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH 206
            .||:|.|::.||:|||.|.....||.:...||.||:..||::||||.|:||||||||:|::.:||
  Fly   346 NLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGH 410

Human   207 IKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGK 271
            :|:||||.:|:..|   :.::.|||.||:|||::..:||.::.|||:.|||::|||.|..||..:
  Fly   411 LKITDFGFAKKLRD---RTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDE 472

Human   272 DRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTI 336
            ........||..|:...:.:.|.|:.|::.|...:...||      |...:|.:::|||.:|..:
  Fly   473 QPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRL------GNMKNGADDVKRHRWFKHL 531

Human   337 DWNKLYRREIHPPFKPATGRPEDTFYFD--PEFTAKTPK 373
            :||.:|.:::.||..|......||..||  ||...|..|
  Fly   532 NWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEKDWKPAK 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	115/306 (38%)
		STKc_RSK2_C	408..737	CDD:271078
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	111/303 (37%)