DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA3 and JIL-1

DIOPT Version :9

Sequence 1:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	250/738 - (33%)
Similarity:	367/738 - (49%)	Gaps:	87/738 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    29 MDEPMGEEEINPQTEEVSIKEIAITHHVK-EGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92
            :|....:.::...|:        :.::|| ...|....:.|::::|||.|::|:||||:|::..|
  Fly   229 LDNEAHQRDLEAVTD--------LKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHD 285

Human    93 ARQLYAMKVLKKATL--KVRDRVRTKMERDILVEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGD 154
            |.:|||||||.|.|:  |.:....||.||.:|..: .:||:|.||||||:..||||:|||..||:
  Fly   286 AGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGE 350

Human   155 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK-ES 218
            |||.|.....|.|..|:.|:||:.|||:.||.|||||||:|.||||||.||||.|:|||||| .:
  Fly   351 LFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILT 415

Human   219 IDHEKKAYSFCGTVEYMAPEVVNR--RGHTQSADWWSFGVLMFEMLTGTLPFQGKD----RKETM 277
            .::|.:|:|||||:||||||::..  .||..:.||||.|||.||:|||..||...|    :.|..
  Fly   416 AENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS 480

Human   278 TMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTIDWNKLY 342
            ..|.|.:..:|...|..|:..:..:.::||..||      |.......|||.|.||:.|:|.:|.
  Fly   481 RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRL------GGNHRDASEIKEHPFFNGINWQELR 539

Human   343 RREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSP-GIPPSANAHQLFRGFSFVAITSDDESQAMQ 406
            .:....|:||.....:|...|..|||.:.|:|.. ..|||  ..:||||:::||
  Fly   540 TKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPS--RIRLFRGYTYVA----------- 591

Human   407 TVGVHSIVQQLHRNS---IQF-----------TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVK 457
                ...::|:.|::   ||:           .|..|:......|:|..|...:..:|::.|..|
  Fly   592 ----PEHLEQMRRDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSSTDLVFLAK 652

Human   458 IIDKSKRDPTEE---IEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE 519
            ||..||..|:|.   |...|....|.||::....:.:....::|.|.:.|.||...|.    ..|
  Fly   653 IIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASIR----MDE 713

Human   520 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 584
            .....:...:...|.::|::..:|.||||.||::  |:....::::.|||.|............|
  Fly   714 DSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKP 776

Human   585 CYTANFVAPEVLKRQG---YDAACDIWSLGVLLYTMLTGYTPFANGPDDTP------EEILARIG 640
            .||.::..||:|....   |..|.||:.||..|||||.|:.|:....||..      .|:..|:.
  Fly   777 RYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMR 841

Human   641 SGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLV 705
            .|.|:.....|.|.|...:.|||..|..||..|.|.:.:|...|:       ||..|..|...::
  Fly   842 RGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWL-------QYGSNDPDVDIIL 899

Human   706 KGAMAATYSALNRNQSPVLEPVG 728
            ...|....|     :..:.:|.|
  Fly   900 PQQMVVDLS-----EDTMEQPTG 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	131/274 (48%)
		STKc_RSK_N	72..394	CDD:270734	152/332 (46%)
		STKc_RSK2_C	408..737	CDD:271078	90/347 (26%)
		Pkinase	428..685	CDD:278497	76/268 (28%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	131/274 (48%)
		STKc_MSK_N	266..533	CDD:270735	132/272 (49%)
		S_TK_X	532..591	CDD:214529	20/60 (33%)
		S_TKc	632..886	CDD:214567	75/259 (29%)
		PKc_like	632..885	CDD:304357	75/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750