Protein Alignment RPS6KA3 and CG4839

DIOPT Version :10

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Alignment Length: 359
• Identity: 115/359 - (32%)
• Similarity: 199/359 - (55%)
• Gaps: 25/359 - (6%)

Human    26 QQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISG 90
            :|:.::|..:.  |..:...|.|.:...:.    :.:...|:.:.:..||.|:||:|.||
  Fly   658 KQLREKPSSQR--NDTSGRSSTKSLEFDNE----YSQVAISELKKIATLGCGAFGRVDLV----- 711

Human    91 SDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFLRGG 153
            :..:|..|:|::||..:..:|:: ....|::::::... ||||:|:..::.:..:|.:::...||
  Fly   712 AYNQQALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGG 776

Human   154 DLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKES 218
            |::|.:||...|.|:..||....:..|.|:|||...|||||||||::|..:|:.||.|||.:| .
  Fly   777 DVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAK-F 840

Human   219 IDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKA 283
            :...:|..:|.||.||:|||::..|||.::.|:|:.|:|::|:|.|..||:|.::.:....||..
  Fly   841 VRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSG 905

Human   284 --KLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTIDWNKLYRREI 346
              .:.||..:...||.|:|.|.|:.||.||      |....|:.:|||||:|.::||.:|..:::
  Fly   906 IDVIHMPSRIPKSAQHLVRHLCKQLPAERL------GYQRKGIADIKRHSWFESLDWQRLKLKQL 964

Human   347 HPPFKPATGRPEDTFYFDP---EFTAKTPKDSPG 377
            ..|.|.......|..||.|   |...:.|::..|
  Fly   965 PSPIKRPLKSWTDLQYFGPSGVENDYEPPEELSG 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	109/313 (35%)
		STKc_RSK2_C	408..737	CDD:271078
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999
		CAP_ED	550..663	CDD:237999	1/4 (25%)
		STKc_cGK	700..957	CDD:270724	98/268 (37%)