Protein Alignment RPS6KA3 and Pkcdelta

DIOPT Version :10

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Alignment Length: 340
• Identity: 143/340 - (42%)
• Similarity: 193/340 - (56%)
• Gaps: 19/340 - (5%)

Human    68 FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDIL-VEVNHPFI 130
            |..|.|||:||||||.|.:.   .|....||:|.|||..:...|.| .|.:||.:| :...||::
  Fly  1566 FHFLAVLGKGSFGKVLLAEL---RDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYL 1627

Human   131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLK 195
            ..|...||||..|:.::::|.||||...:.:...|:||..:||.||:...|..||..||||||||
  Fly  1628 CHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLK 1692

Human   196 PENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFE 260
            .:|:|||.|||:::.|||:.|..|..:|.|.|||||.:|||||::....:.|:.||||||||::|
  Fly  1693 LDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYE 1757

Human   261 MLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVE 325
            ||.|..||.|.|..|....|.......|.::|.||..:|:.|.:::...|:.:.:    .|.|
  Fly  1758 MLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQY----SPAG-- 1816

Human   326 EIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----TPKDSPGIPPSANAHQ 386
            :|..|.||..|||..|.:|:|.|||||....|.||.|||..||.:    ||.|.. |..|.:..|
  Fly  1817 DIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKE-ILASMDQKQ 1880

Human   387 LFRGFSFV--AITSD 399
             |.||::.  .||.|
  Fly  1881 -FHGFTYTNPHITLD 1894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	138/327 (42%)
		STKc_RSK2_C	408..737	CDD:271078
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	138/329 (42%)