DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA3 and rskn-1

DIOPT Version :9

Sequence 1:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens
Sequence 2:	NP_001122504.1	Gene:	rskn-1 / 172647	WormBaseID:	WBGene00011352	Length:	804	Species:	Caenorhabditis elegans

Alignment Length:	774	Identity:	450/774 - (58%)
Similarity:	556/774 - (71%)	Gaps:	49/774 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLAQLADPW-------------------QKMAVESPSDSAE----------NGQQIMDEP--MG 34
            ||||||.:|:                   .:|.|...||..:          :...|:..|  .|
Worm     1 MPLAQLGEPFGITPSSIENVSPGIDQCKDHRMDVSMRSDPTDCSSDTTNTFHSSIHIIQPPPNNG 65

Human    35 EEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAM 99
            ...:|.:|:..|..||.| ..|::..|||||.|||||||||||||||||||:|:.|.|:..:|||
Worm    66 FRLMNWKTDSSSETEIDI-GDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAM 129

Human   100 KVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM 164
            |||||||||||||.|||:||:||..::||||||||||||||||||||||||||||||||||||||
Worm   130 KVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM 194

Human   165 FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFC 229
            |||:|||||||||.|||:|||||||:||||||||||||.:||||:||||||||:||.|||.||||
Worm   195 FTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFC 259

Human   230 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPE 294
            ||||||||||:|||||:.:||:||.||||||||||.|||||:||.:|||.||||||.||.||:.|
Worm   260 GTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQE 324

Human   295 AQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPED 359
            ||||||.|||||..|||      |||||||||||||:||:.||:.||..:||.||||||....:.
Worm   325 AQSLLRALFKRNSQNRL------GAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDS 383

Human   360 TFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQF 424
            |.|||||||.:||||||.:|.|||.|::|||||||: .:..|.:.:....|.|:..   ..:..|
Worm   384 TSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS-NAVMEERKLIAKSVRSVPT---AKTNPF 444

Human   425 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVY 489
            ||.||:.|.||.|::||..:|..|||..::||||:.|:..|.|||::||||:..|..::.|.|||
Worm   445 TDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVY 509

Human   490 DDGKYVYVVTELMKGGELLDKILRQKFF-SEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILY 553
            :|...:|::.||.:|||||||::.:|.. ||:|.:|::..:...|:|||:|.|.||||..:|||:
Worm   510 EDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILF 574

Human   554 VDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTML 618
            ..:.|:|.|:||.|||||||.|||||:||||||||.|||||||::||||.:||:|||||||:|||
Worm   575 ALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTML 639

Human   619 TGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHP 683
            ||.||||.||:|||::||.|:|.||.|::...|:::||.|||||.|||.|||::|:||...|:|.
Worm   640 TGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHK 704

Human   684 WIVHWDQLPQYQLNRQDAPHL------VKGAMAATYSALNRNQSPVLEPVGRSTLAQRR 736
            ||...:.||...:..:....|      .:.|:..||.|:....|..|.|||.|.||:||
Worm   705 WIGQKEALPDRPIQSEQVGELDMQNVKFQVALEQTYKAIASAPSVQLRPVGSSALAKRR 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	214/264 (81%)
		STKc_RSK_N	72..394	CDD:270734	248/321 (77%)
		STKc_RSK2_C	408..737	CDD:271078	168/336 (50%)
		Pkinase	428..685	CDD:278497	144/257 (56%)
rskn-1	NP_001122504.1	S_TKc	98..357	CDD:214567	214/264 (81%)
		STKc_RSK_N	102..418	CDD:270734	248/321 (77%)
		STKc_RSK_C	447..744	CDD:270993	153/296 (52%)
		S_TKc	448..706	CDD:214567	144/257 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I292
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	870	1.000	Inparanoid score	I212
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm15396
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910