Protein Alignment RPS6KA3 and rps6ka3

DIOPT Version :9

• Sequence 1: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Sequence 2: XP_031752603.1
• Gene: rps6ka3 / 100496161
• XenbaseID: XB-GENE-480947
• Length: 737
• Species: Xenopus tropicalis
• Alignment Length: 738
• Identity: 676/738 - (91%)
• Similarity: 698/738 - (94%)
• Gaps: 11/738 - (1%)

Human     1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADP 65
            ||||||||||||:.|:..  .:|||||..||.|.:|: |...:|.:|.|||||||||||||||||
 Frog     1 MPLAQLADPWQKVPVQKV--GSENGQQFADESMCDED-NENNDEGNINEIAITHHVKEGHEKADP 62

Human    66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFI 130
            ||||||||||||||||||||:||||:||.||||||||||||||||||||||||||||||||||||
 Frog    63 SQFELLKVLGQGSFGKVFLVRKISGTDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFI 127

Human   131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLK 195
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
 Frog   128 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKYYLAELALALDHLHSLGIIYRDLK 192

Human   196 PENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFE 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   193 PENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFE 257

Human   261 MLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVE 325
            |||||||||||||||||||||||||||||||:|||||||||||||||.|||      ||||||||
 Frog   258 MLTGTLPFQGKDRKETMTMILKAKLGMPQFLTPEAQSLLRMLFKRNPTNRL------GAGPDGVE 316

Human   326 EIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRG 390
            |||||.||:|||||||||||..||||||||.|||||||||||||||||||||||.||||||||||
 Frog   317 EIKRHPFFATIDWNKLYRRENQPPFKPATGGPEDTFYFDPEFTAKTPKDSPGIPASANAHQLFRG 381

Human   391 FSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFA 455
            ||||||||:||:|||||||||:|| .|||||||||||||:||||||||||:|||||||.||||:|
 Frog   382 FSFVAITSEDENQAMQTVGVHAIV-PLHRNSIQFTDGYELKEDIGVGSYSICKRCIHKGTNMEYA 445

Human   456 VKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSER 520
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
 Frog   446 VKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMKGGELLDKILRQKFFSER 510

Human   521 EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC 585
            ||||||.||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||
 Frog   511 EASAVLHTITKTVEYLHSQWVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC 575

Human   586 YTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   576 YTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 640

Human   651 WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA 715
            ||||||.||||||||||||||||||||.||:||||||.|||||:|||||||||||||||||||||
 Frog   641 WNSVSDIAKDLVSKMLHVDPHQRLTAAQVLKHPWIVHCDQLPQFQLNRQDAPHLVKGAMAATYSA 705

Human   716 LNRNQ-SPVLEPVGRSTLAQRRG 737
            ||.|. |||||||||||||||||
 Frog   706 LNLNPLSPVLEPVGRSTLAQRRG 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	251/264 (95%)
		STKc_RSK_N	72..394	CDD:270734	303/321 (94%)
		STKc_RSK2_C	408..737	CDD:271078	310/329 (94%)
		Pkinase	428..685	CDD:278497	245/256 (96%)
rps6ka3	XP_031752603.1	STKc_RSK_N	69..385	CDD:270734	303/321 (94%)
		STKc_RSK2_C	399..737	CDD:271078	312/331 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	508	1.000	Domainoid score	I3600
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37940
Inparanoid	1	1.050	1367	1.000	Inparanoid score	I1739
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		oto149089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980